GSM862723[Accession] - GEO DataSets

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Items: 4

Select item 2000513341.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...

Organism:: Homo sapiens; Mus musculus

Type:: Other

25 related Platforms
993 Samples

Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT

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Accession:: GSE51334

ID:: 200051334

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000351562.

Conserved Topological Domains in Mammalian Genomes Identified by High-resolution Analysis of Chromatin Interactions

(Submitter supplied) The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is limited. Here we present high-resolution analyses of chromosomal organization in pluripotent and differentiated human and murine cell types determined using the Hi-C technique. We find that the mammalian genome is composed of over 1000 topological domains, which are stable among different cell types and highly conserved across species. more...