GSM874632[Accession] - GEO DataSets

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Items: 4

Select item 2000357741.

Suppression of the antiviral response by an influenza "histone mimic"

(Submitter supplied) Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 target the transcription elongation PAF1 complex (hPAF1C). We demonstrate that binding of NS1 to hPAF1C results in suppression of hPAF1C-mediated transcriptional elongation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL10999 GPL11154
17 Samples

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Accession:: GSE35774

ID:: 200035774

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000352682.

Analysis of global gene expression profiles of hPAF1 deficient A549 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing