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Items: 3

1.

Enhancer Remodeling-Driven Mevalonate Pathway Confers Resistance to KRAS Inhibitor in Colorectal Cancer

(Submitter supplied) This study investigates the resistance mechanisms to pan-KRAS inhibitors in colorectal cancer (CRC). We established a panel of patient-derived organoids (PDOs) and cell lines with differential sensitivity to pan-KRAS inhibitors. Integrated epigenomic (ChIP-seq for H3K27ac and H3K4me3) and transcriptomic (RNA-seq) profiling revealed that enhancer remodeling drives compensatory activation of the mevalonate (MVA) pathway in resistant models. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL20301
12 Samples
Download data: BW, XLSX
Series
Accession:
GSE306909
ID:
200306909

2.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
9284 Series
214822 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

3.

LS174T-P_H3K4me3,LS174T parental, H3K4me3 ChIP-seq

Organism:
Homo sapiens
Source name:
LS174T
Platform:
GPL20301
Series:
GSE306909
Download data: BW
Sample
Accession:
GSM9212126
ID:
309212126

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db=gds|term=GSM9212126[Accession]|query=1|qty=2|blobid=MCID_698646adef03752f27aaec49|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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