GEO DataSets

(Submitter supplied) Transcriptional analysis of the drug resistant strain L. major MTX60.4 compared to the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance

Organism:

Leishmania major; Leishmania infantum

Type:

Expression profiling by array

Platform:

GPL6855

4 Samples

Download data: GPR

(Submitter supplied) CGH analysis of the drug resistant strain L. major MTX60.4 vs the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance

Organism:

Leishmania major; Leishmania infantum

Type:

Genome variation profiling by array

Platform:

GPL6855

3 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Leishmania major; Leishmania infantum

Type:

Expression profiling by array

Platform:

GPL6855

8 Samples

Download data: GPR

(Submitter supplied) Transcriptional analysis of the drug resistant strain L. infantum MTX20.5 compared to the wild-type strain The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L. infantum Keywords: drug resistance

Organism:

Leishmania major; Leishmania infantum

Type:

Expression profiling by array

Platform:

GPL6855

4 Samples

Download data: GPR

(Submitter supplied) The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. more...

Organism:

Leishmania infantum

Type:

Expression profiling by array

Platform:

GPL8804

5 Samples

Download data: GPR

(Submitter supplied) Transcriptional analyses of L. infantum promastigote compared to L. infantum intracellular amastigote, and L. major promastigote compared to L. major intracellular amastigote The full-genome DNA microarray includes one 70mer-oligonucleotide probe for each gene of L. infantum and for each gene of L.major LV39 Keywords: stage-specific comparison

Organism:

Leishmania infantum; Leishmania major

Type:

Expression profiling by array

Platform:

GPL6855

10 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Leishmania major; Leishmania mexicana

Type:

Expression profiling by array

Platform:

GPL3505

11 Samples

Download data: TXT

(Submitter supplied) We examined the Leishmania mexicana transcriptome to identify differentially regulated mRNAs using high-density whole-genome oligonucleotide microarrays designed from the genome data of a closely related species, Leishmania major. Statistical analysis on array hybridization data representing 8156 predicted coding regions revealed 288 genes (3.5% of all genes) whose steady-state mRNA levels meet criteria for differential regulation between promastigotes and lesion-derived amastigotes. more...

Organism:

Leishmania major; Leishmania mexicana

Type:

Expression profiling by array

Platform:

GPL3505

9 Samples

Download data: TXT

(Submitter supplied) We examined the Leishmania mexicana transcriptome to identify differentially regulated mRNAs using high-density whole-genome oligonucleotide microarrays designed from the genome data of a closely related species, Leishmania major. This experiment appears as Fig. 1 of the associated publication. Keywords: RNA expression profiling

Organism:

Leishmania major; Leishmania mexicana

Type:

Expression profiling by array

Platform:

GPL3505

4 Samples

Download data: TXT

(Submitter supplied) This platform supports 11 60-mer DNA oligonucleotide probes synthesized twice on each slide for 8160 (98%) of the Leishmania major Friedlin genes annotated at www.genedb.org. Refer to: Timothy R. Holzer, W.R. McMaster, James D. Forney. “Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicana.” Molecular and Biochemical Parasitology 146 (2): 198-218. more...

Organism:

Leishmania major

3 Series

11 Samples

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(Submitter supplied) Purpose: Monitor modulation of aneuploidy in Leishmania donovani during adaptation to different in vitro and in vivo environments, and its impact on gene expression Importance: Aneuploidy is usually detrimental in multicellular organisms, but in several micro-organisms (fungi being the best-studied) it can be tolerated and even beneficial. Leishmania – a protozoan parasite killing more than 30,000 persons each year – is emerging as a new model for aneuploidy studies: unexpectedly high levels of aneuploidy are found in clinical isolates. more...

Organism:

Leishmania donovani

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23261

11 Samples

Download data: TXT

(Submitter supplied) This study describes the application of the LongSAGE methodology to study the gene expression profile in Leishmania infantum chagasi. A tag library was created using the LongSAGE method and consisted of 14,208 tags of 17 bases. Of these, 8,427 (59.3%) were distinct. BLAST research of the 1,645 most abundant tags showed that 12.8% of them identified the coding sequences of genes, while 82% (1,349/1,645) identified one or more genomic sequences that did not correspond with open reading frames. more...

Organism:

Leishmania chagasi

Type:

Expression profiling by SAGE

Platform:

GPL11414

1 Sample

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(Submitter supplied) Leishmania are ancient eukaryotes that have retained the ability to produce extracellular vesicles (EVs) through evolution. Until date, it was unclear if different DNA entities could be associated to Leishmania EVs, and whether these could constitute a novel mechanism of horizontal gene transfer (HGT). Herein, we investigated the DNA content of EVs derived from drug-resistant parasites, as well as the potential of EVs as shuttles for DNA transfer. more...

Organism:

Leishmania infantum

Type:

Other

Platform:

GPL32139

6 Samples

Download data: BW, CSV