Similar studies for GEO DataSets (Select 200070624) - GEO DataSets

Select item 2000706241.

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq]

(Submitter supplied) Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: BED

Series

Accession:: GSE70624

ID:: 200070624

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000749602.

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [Kras background mouse gene expression]

(Submitter supplied) Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18233
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE74960

ID:: 200074960

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000749593.

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression]

(Submitter supplied) Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE74959

ID:: 200074959

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000707294.

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms
40 Samples

Download data: BED, CEL, CHP

Series

Accession:: GSE70729

ID:: 200070729

PubMed Full text in PMC Similar studies

Select item 2000707285.

Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]

(Submitter supplied) Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: DIFF

Series

Accession:: GSE70728

ID:: 200070728

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001602876.

The histone demethylase KDM2B regulates human primordial germ cell-like cells specification

(Submitter supplied) Germline specification is a fundamental step for human reproduction and this biological phenomenon possesses technical challenges to study in vivo as it occurs immediately after blastocyst implantation. The establishment of in vitro human primordial germ cell-like cells (hPGCLCs) induction system allows sophisticated characterization of human primordial germ cells (hPGCs) development. However, the underlying molecular mechanisms of hPGCLC specification are not fully elucidated. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
12 Samples

Download data: TSV

Series

Accession:: GSE160287

ID:: 200160287

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000413167.

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL6246
12 Samples

Download data: CEL, WIG

Series

Accession:: GSE41316

ID:: 200041316

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000413148.

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [ChIP-Seq]

(Submitter supplied) Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs). However, the mechanisms by which PcG proteins are recruited to their targets are largely unknown. Here, we show that the histone demethylase Kdm2b is highly expressed in mESCs and regulated by the pluripotent factors Oct4/Sox2 directly. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: WIG

Series

Accession:: GSE41314

ID:: 200041314

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000412989.

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [Expression profiling]

(Submitter supplied) Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs). However, the mechanisms by which PcG proteins are recruited to their targets are largely unknown. Here, we show that the histone demethylase Kdm2b is highly expressed in mESCs and regulated by the pluripotent factors Oct4/Sox2 directly. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE41298

ID:: 200041298

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002778710.

Hematopoietic cells and stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3997
Platform:: GPL1261
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE27787

ID:: 200027787

Select item 20002778611.

Gene expression profile of mouse hematopoietic cells

(Submitter supplied) Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
20 Samples

Download data: CEL, CHP

Series

Accession:: GSE27786

ID:: 200027786

Select item 20002778512.

Gene expression profile of mouse hematopoietic stem cells

(Submitter supplied) Mouse CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors were purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and their gene expression was analyzed.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE27785

ID:: 200027785

Select item 399713.

Various bone marrow hematopoietic cell fractions

Analysis of BM hematopoietic cell fractions including CD34-KSL hematopoietic stem cells. HSCs are primitive cells capable of both self-renewal and differentiating into all of the mature blood cell lineages. Results provide insight into molecular mechanisms underlying maintenance of HSC self-renewal.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 12 cell type sets

Platform:: GPL1261
Series:: GSE27787
24 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3997

ID:: 3997

Select item 20008104314.

Silencing of KDM2B leads to deregulation of apoptosis related genes in GBM

(Submitter supplied) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-cancer protein that can specifically kill tumor cells while sparing healthy ones. Emerging evidences suggest that TRAIL resistance in cancers is associated with aberrant expression of the key components of the apoptotic program. However, how these components are regulated at the epigenetic level is not understood. In this study, we aimed to identify novel epigenetic mechanisms regulating TRAIL response in Glioblastoma Multiforme (GBM) by a short-hairpin RNA (shRNA) screen. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: XLSX

Series

Accession:: GSE81043

ID:: 200081043

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20019650715.

Transcriptome and epigenetic characterization of ECs during VEGF-signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
19 Samples

Download data: BIGWIG

Series

Accession:: GSE196507

ID:: 200196507

PubMed Similar studies

Select item 20019650516.

RNA-seq analysis to examine the effect of KDM2B knockdown or overexpression on transcriptional responses in ECs during VEGF-signaling

(Submitter supplied) Vascular endothelial growth factor (VEGF) signaling serves a central role in vascular development as well as maintaining vascular homeostasis. In endothelial cells (ECs), VEGF activates gene expression of angiogenic transcription factors (TFs) followed by downstream induction of angiogenic responsive genes. Recent findings support histone modification dynamics contribute to transcriptional control of genes important for EC functions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
15 Samples

Download data: BIGWIG

Series

Accession:: GSE196505

ID:: 200196505

Select item 20019650317.

Genome-wide distribution of histone modification H3K36me3 in ECs during VEGF-signaling

(Submitter supplied) Vascular endothelial growth factor (VEGF) signaling serves a central role in vascular development as well as maintaining vascular homeostasis. In endothelial cells (ECs), VEGF activates gene expression of angiogenic transcription factors (TFs) followed by downstream induction of angiogenic responsive genes. Recent findings support histone modification dynamics contribute to transcriptional control of genes important for EC functions. more...