GEO DataSets

(Submitter supplied) We applied scATAC-seq to construct a cell type-specific epigenetic landscape of kidney at single-cell resolution.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL24676 GPL18573

2 Samples

Download data: BED, CSV, RDS

(Submitter supplied) Between 80% and 90% of renal carcinomas are either clear cell renal cell carcinoma or papillary RCC although there are at least 20 other distinct forms of RCC recognised by the World Health Organization (WHO). Emerging or provisional entities have been considered as variants of PRCC, including papillary renal neoplasm with reversed polarity (PRNRP). However, the molecular basis of PRNRP, and miRNA expression profile, is unknown. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

10 Samples

Download data: CEL, CHP

(Submitter supplied) Between 80% and 90% of renal carcinomas are either clear cell renal cell carcinoma or papillary RCC although there are at least 20 other distinct forms of RCC recognised by the World Health Organization (WHO). Emerging or provisional entities have been considered as variants of PRCC, including papillary renal neoplasm with reversed polarity (PRNRP). However, the molecular basis of PRNRP is unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24539

17 Samples

Download data: CEL, CHP

(Submitter supplied) BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological classification of PRCC into Type 1 and Type 2 tumors has been recently proposed, but its biological relevance remains uncertain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1344

Platform:

GPL570

34 Samples

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Analysis of renal tumors from 34 papillary renal cell carcinoma (PRCC) cases. Results identify 2 molecular signatures that correlate with the morphologic classification of PRCC. Molecular class type 1 tumors correlate with excellent survival, while type 2 tumors correlate with poor survival.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 2 other sets

Platform:

GPL570

Series:

GSE2748

34 Samples

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(Submitter supplied) MicroRNAs play a vital role in the process of tumorigenesis. To identify and characterize miRNA Expression in renal cell cancer, we performed microarray based screening of miRNA expression profiles in clear cell, papillary type 1 and papillary type 2 renal cell cancer.

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

38 Samples

Download data: CEL

(Submitter supplied) Purpose: Using single-cell RNA sequencing (scRNAseq), Young et al. (Science, 2018, PMID 30093597) recently identified a canonical cancer transcriptome as the possible cell of origin of papillary renal cell carcinoma (pRCC) that matched a rare proximal convoluted tubular cell population characterized as VCAM1+ SLC17A3+ SLC7A13-, a cell cluster signature defined as PT1. The goal of this study is to compare pRCC transcriptome to human renal progenitor cell (RPC) transcriptome. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21697

4 Samples

Download data: MTX, TSV

(Submitter supplied) We aimed to use next-generation sequencing that may provide intriguing insights into the molecular pathways mediating anti-tumor activity for HSP90 inhibitor, SNX2112 in papillary renal cancer. Our findings uncovered unique set of target genes and pathways of significance in papillary renal cancer that have potential to be translated into clinically effective therapeutic strategies for patients.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21290

10 Samples

Download data: TXT

(Submitter supplied) Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. To better understand the biology of this tumor, we analyze the miRNA expression profiles of a set of CCPRCC by microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16770

8 Samples

Download data: TXT