GEO DataSets

(Submitter supplied) Copy-number and loss of heterozygosity analysis of salivary gland tumors in a proband with attenuated familial adenomatous polyposis (AFAP), using Affymetrix OncoScan and CytoScan HD arrays

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL21558

3 Samples

Download data: CEL, OSCHP

(Submitter supplied) Intercalated duct hyperplasia, basal cell adenoma and basal cell adenocarcinomas of the proband were analyzed by spatial transcriptomics and demonstrated a stepwise increase in WNT activation from benign to malignant lesions

Organism:

Homo sapiens

Type:

Other

Platform:

GPL30173

28 Samples

Download data: DCC, PKC, XLSX

(Submitter supplied) Gastric adenocarcinoma and proximal polyposis of the stomach is an autosomal dominant cancer predisposition syndrome of fundic gland polyposis with a significant risk of gastric adenocarcinoma. We mapped the gene to 5q22 and found loss of heterozygosity (LOH) only on 5q in fundic gland polyps from affected individuals. Sanger sequencing revealed novel point mutations in APC promoter 1B that co-segregated with disease. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL18952

14 Samples

Download data: IDAT, TXT

(Submitter supplied) Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended expression signatures of difficult functional interpretation. The majority of sporadic colorectal cancer cases are triggered by mutations in the APC tumor suppressor gene leading to constitutive activation of the Wnt/b-catenin signaling pathway and adenoma formation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3408

78 Samples

Download data: GPR

(Submitter supplied) The majority of sporadic colorectal cancer cases are initiated by mutations in the APC tumor suppressor gene leading to constitutive activation of the Wnt/b-catenin signaling pathway and adenoma formation. Several pre-clinical models carrying germline mutations in the endogenous mouse Apc tumor supressor gene have been generated and their phenotype characterized. The predisposition of these mouse models to multiple intestinal adenomas closely resembles the FAP phenotype at the molecular, cellular and phenotypic level and may prove valuable to elucidate the molecular and cellular mechanisms underlying colorectal tumorigenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

5 Samples

Download data: CEL