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Items: 1 to 20 of 106696

1.

Influence of Pleurotus sapidus fruiting bodies on performance, cecum microbiome and intermediary metabolism in liver and breast muscle of broilers

(Submitter supplied) Despite the need to enhance feed production for monogastric farm animals, this challenge is complicated by the fact that natural resources are becoming increasingly limited and climate protection goals have to be considered. Thus, there is a need for alternative feed sources, which are produced in a resource-efficient and sustainable manner. Valorization of low-value agricultural sidestreams by edible fungi, such as Pleurotus sapidus (PSA), has been proposed as a strategy to utilize such sidestreams as a sustainable source of feed for monogastric farm animals, because P. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL19014
18 Samples
Download data: CEL, XLSX
Series
Accession:
GSE288500
ID:
200288500
2.

Transcriptomic profiling of host response genes in convalescent COVID-19 donors and healthy controls using the NanoString nCounter Human Host Response V1.0 Panel

(Submitter supplied) NanoString nCounter assay was performed to measure the basal expression of host response genes in primary human monocytes from convalescent COVID-19 donors and SARS-CoV-2 naïve healthy individuals.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL30506
23 Samples
Download data: RCC
Series
Accession:
GSE181958
ID:
200181958
3.

SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells

(Submitter supplied) To explore new therapeutic approaches, we identified genes specifically expressed in mesothelioma stem cell-like cells derived from human mesothelioma cell lines using hydrogel-based stem cell induction method. Gene expression in ACC-MESO-4 cells cultured on double network (DN) hydrogel composed of poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) and poly(N,N’-dimethylacrylamide) (PDMAAm) was compared to that on control polystyrene (PS) dish and on ultra-low attachment (ULA) dish, a classical method for enriching stem cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
3 Samples
Download data: TXT, XLSX
Series
Accession:
GSE286050
ID:
200286050
4.

Chronic Salmonella Infection Contributes to Gallbladder Carcinogenesis by Host Epigenetic Modifications

(Submitter supplied) The present study aimed to understand the pathways involved in gallbladder cancer through genome-wide expression profiling (microarray) of human GBC
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
32 Samples
Download data: TXT
Series
Accession:
GSE255497
ID:
200255497
5.

Cortex and Hypothalamus Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats: Affymetrix Microarray Data from Generation F4

(Submitter supplied) The strong pattern of comorbidity amongst psychiatric disorders is believed to be generated by a spectrum of latent liability, arising from a complex interplay of genetic risk and environmental factors, such as stress and childhood adversity. At one end of this spectrum are internalizing disorders, which are associated with neuroticism, anxiety, and depression. At the other end of the spectrum are externalizing disorders, which are associated with risk-taking and novelty-seeking, as seen in mania, substance abuse, and impulse-control disorders. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL35276
24 Samples
Download data: CEL
Series
Accession:
GSE286181
ID:
200286181
6.

Real-time quantitative PCR analysis of EV-containing miRNA from human adipocytes SGBS cells

(Submitter supplied) Mature adipocytes were pretreated with VD for 24h and/or treated with TNFα during 24h. EVs released by adipocytes after TNF treatment were isolated and the miRNAs contained in it were extracted for qPCR analysis.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL35130
4 Samples
Download data: TXT
Series
Accession:
GSE282819
ID:
200282819
7.

Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling

(Submitter supplied) Therapeutic resistance to immune checkpoint blockade has been commonly linked to the process of mesenchymal transformation (MT) and remains a prevalent obstacle across many cancer types. An improved mechanistic understanding for MT-mediated immune evasion promises to lead to more effective combination therapeutic regimens. Herein, we identify the Hedgehog transcription factor, Gli2, as a key node of tumor-mediated immune evasion and immunotherapy resistance during MT. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL29668
39 Samples
Download data: RCC
Series
Accession:
GSE280470
ID:
200280470
8.

Genotype-Driven Sensitivity in Mice to Tick-Borne Encephalitis Virus Correlates with Differential Host Responses in Peripheral Macrophages and Brain

(Submitter supplied) Tick-borne encephalitis (TBE) is the most common tick-borne viral infection in Eurasia, with outcomes ranging from asymptomatic to fatal encephalitis. While the reasons for this variability are unclear, host genetics likely plays a role. Our previous research showed that BALB/c mice have intermediate susceptibility to TBE virus (TBEV), STS mice are highly resistant, and the recombinant congenic strain CcS-11, which has 12.5% of the STS genome on the BALB/c background, is more susceptible than the BALB/c. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE276086
ID:
200276086
9.

gene expression data of granulosa cells treated with DMSO or LY294002

(Submitter supplied) PI3K-AKT signaling is essential for various cellular processes, including cell viability, proliferation, and metabolism. Here, we investigated the genome-wide changes induced by PI3K-AKTsignaling in primary granulosa cell cultures treated with control (DMSO) and PI3K-AKT pathway inhibitor LY294002.
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL16500
6 Samples
Download data: CEL
Series
Accession:
GSE274651
ID:
200274651
10.

Modulation of biological activities in adipose derived stem cells by histone deacetylation

(Submitter supplied) Epigenetic mechanisms control stem cell homeostasis and differentiation as well as skin regeneration. In our study, we investigated the effects of Suberoylanilide hydroxamic acid (SAHA) on stem cells to understand the cellular and molecular impact. Adipose-derived stem cells received consecutive SAHA treatment for 72 hours. No change in the cell viability could be noticed at the studied concentrations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL34587
8 Samples
Download data: CEL
Series
Accession:
GSE269774
ID:
200269774
11.

Metastatic signature for Ewing’s sarcoma

(Submitter supplied) Ewing sarcoma (ES) is the second most common bone tumor affecting children and young adults, with dismal outcomes for patients with metastasis at diagnosis. Mechanisms leading to metastasis remain poorly understood. To deepen our knowledge on ES progression, we have profiled tumors and metastases from a spontaneous metastasis mouse model using a multi-omics approach. Combining transcriptomics, proteomics and methylomics analyses, we identified signaling cascades and targets enriched in metastases that could be modulating aggressiveness in ES. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23126
21 Samples
Download data: CEL, CHP
Series
Accession:
GSE246220
ID:
200246220
12.

Curcumin reverses irinotecan-acquired resistance in colorectal cancer cells: insights from whole transcriptomic data

(Submitter supplied) To investigate the key mechanisms underlying the acquisition of irinotecan resistance in colorectal cancer cells and the reversal of this resistance by curcumin, we utilized whole-genome microarray expression profiling as a discovery tool to identify the signaling networks involved. Resistance acquisition led to dysregulation of genes associated with irinotecan resistance, including TOP1, drug-metabolizing enzymes (CYPs and UGTs), and efflux transporters (ABCs), while also affecting the extression of 53 genes involed in proliferation and 33 in cell motility. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
11 Samples
Download data: TXT
Series
Accession:
GSE288308
ID:
200288308
13.

Perturbed mouse Epiblast Stem Cells (EpiSC) with Retinoic acid and small molecule compounds at different time points

(Submitter supplied) EpiSC were perturbed for 24h or 36h with Retinoic acid and 10 distinct small molecule compounds, mouse embryonic fibroblasts conditioned media (CM) or control basal media (Mock)
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
36 Samples
Download data: TXT
Series
Accession:
GSE197632
ID:
200197632
14.

Perturbed mouse Epiblast Stem Cells (EpiSC)

(Submitter supplied) EpiSC were perturbed for 36h with 33 distinct small molecule compounds, and for 24h with 7 different differentiation morphogens or control culture conditions
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
276 Samples
Download data: TXT
Series
Accession:
GSE197414
ID:
200197414
15.

Genomic landscape of DNA methylation following m6A demethylation

(Submitter supplied) ALKBH5 has been recognized as a major RNA m6A demethylase in human cells. Here, we show that genomic DNA methylation is reshaped following the transcriptomic m6a demethylation. ALKBH5-KD human colon cancer cell line HCT116 was constructed. The genomic DNA was extracted to profile the genome-wide methylation.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
6 Samples
Download data: IDAT, XLSX
Series
Accession:
GSE196028
ID:
200196028
16.

Genomic landscape of DNA methylation following APOBEC3A-induced mutation

(Submitter supplied) APOBEC-induced genomic mutation a major driver of cancer evolution. Here, we show that genomic DNA methylation is reshaped following the APOBEC-induced genomic mutation.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
6 Samples
Download data: IDAT, XLSX
Series
Accession:
GSE196027
ID:
200196027
17.

Cell-type-specific efferocytosis determines functional plasticity of alveolar macrophages

(Submitter supplied) Acid aspiration of gastric contents leads to aspiration pneumonitis, and as such predisposes to severe secondary bacterial infections. Alveolar macrophages are key sentinel cells in the lung, which initiate and resolve an inflammatory process. We found that after acid aspiration resident alveolar macrophages are impaired in their capacity to eliminate the clinically relevant bacterium Pseudomonas aeruginosa ex vivo and in vivo. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
32 Samples
Download data: GPR
Series
Accession:
GSE287821
ID:
200287821
18.

Sequential Transcriptome Profiling: Comparative Analysis of Normal and Canine Lymphoma Preceding Detailed T-Cell and B-Cell Subtype

(Submitter supplied) This study aimed to delineate genes and functional pathways related to canine lymphoma pathogenesis, treatment response, and prognosis through transcriptional profiling. By comparing different lymphoma subtypes, the study aimed to identify genes with potential applicability to the clinical characteristics of T-cell lymphoma (TCL) compared to B-cell type, which is characterized by low treatment response and poor prognosis.
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL15379
17 Samples
Download data: TXT, XLSX
Series
Accession:
GSE285369
ID:
200285369
19.

Expression data of small and large intestinal epitheliall cells from Nfat5fl/fl and Nfat5IEC-KO mice

(Submitter supplied) Gene expression profile data of small and large intestinal epitheliall cells from Nfat5fl/fl and Nfat5IEC-KO mice We used microarrays to detail the global programme of gene expression of small and large intestinal epitheliall cells from Nfat5fl/fl and Nfat5IEC-KO mice and identified differential genes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE256421
ID:
200256421
20.

METTL3-m6A methylation inhibits Type II Alveolar Epithelial Cells proliferation and viability by promoting Pten mRNA stability and translation efficiency in the acute lung injury

(Submitter supplied) In this dataset, we include the m6A methylated RNA data obtained from normal AECII (NC group) and AECII transfected with shMettl3 (T group).
Organism:
Mus musculus
Type:
Expression profiling by array; Other
Platform:
GPL25915
12 Samples
Download data: TXT
Series
Accession:
GSE256239
ID:
200256239
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