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Items: 1 to 20 of 179758

1.

Integrative Gene and Isoform Co-expression Networks Reveal Regulatory Rewiring in Stress-related Psychiatric Disorders [PBMC]

(Submitter supplied) Isoform-specific expression patterns have been implicated in stress-related psychiatric disorders like major depressive disorder (MDD), yet the extent of their involvement and their interrelationships remain unclear. We constructed co-expression networks for individuals affected (n=210, 81% with depressive symptoms) and unaffected (n=95) by stress-related psychiatric disorders. We incorporated total gene expression (TE) and isoform ratio (IR) data and validated the inferred networks using advanced graph generation techniques. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
299 Samples
Download data: RESULTS
Series
Accession:
GSE289146
ID:
200289146
2.

Integrative Gene and Isoform Co-expression Networks Reveal Regulatory Rewiring in Stress-related Psychiatric Disorders [whole blood]

(Submitter supplied) Isoform-specific expression patterns have been implicated in stress-related psychiatric disorders like major depressive disorder (MDD), yet the extent of their involvement and their interrelationships remain unclear. We constructed co-expression networks for individuals affected (n=210, 81% with depressive symptoms) and unaffected (n=95) by stress-related psychiatric disorders. We incorporated total gene expression (TE) and isoform ratio (IR) data and validated the inferred networks using advanced graph generation techniques. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
37 Samples
Download data: RESULTS
Series
Accession:
GSE289144
ID:
200289144
3.

Lucicebtide (ST101) effect on hPBMCs-derived M2-type macrophages.

(Submitter supplied) Reprogramming immunosuppressive M2-like macrophage to immune-active M1-like macrophage represents a promising strategy to improve responses to immunotherapy. Lucicebtide (previously referred to as ST101) is a peptide antagonist of the transcription factor C/EBPβ, a key activator of the transcriptional program in immunosuppressive macrophages. We show that Lucicebtide exposure reprograms human Perypheral Blood Mononuclear cells (hPBMSc)-derived M2-like macrophage to the pro-inflammatory M1-like phenotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34284
6 Samples
Download data: TXT
Series
Accession:
GSE288861
ID:
200288861
4.

Expression data from HoxA9wt/Meis1 vs. HoxA9AA/Meis1 mouse models

(Submitter supplied) To verify the impact of eIF4E activation on HoxA9-induced leukemic transformation in vivo, we made a double point mutation (HoxA9AA) to disrupt the physical and functional interaction between eIF4E and HOXA9. Microarray analysis of transformed leukemic cell lines derived from HoxA9wt/Meis1 and HoxA9AA/Meis1 leukemic cells presented highly similar transcriptome profile, without any significant changes of HoxA9 gene signature.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE288783
ID:
200288783
5.

Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Pms1 heterozygous and homozygous mice

(Submitter supplied) Cerebral cortex and striatum were isolated from 6-month old Pms1+/- and Pms1-/- mice crossed with the Q140 knock-in (KI) mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 6 genotypes: WT, Q140, Psm1+/-, Q140 X Psm1+/-, Psm1-/-, and Q140 X Psm1-/-, 8 replicates per genotype.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
96 Samples
Download data: TXT
Series
Accession:
GSE288739
ID:
200288739
6.

Wild-Type vs ORAI 1/2/3 TKO_Pathogenic Th17 cells_ 6h vs 24h

(Submitter supplied) Time-Course Transicriptome comparison between murine WT and ORAI TKO pTH17cells at 6 hours and 24 hours following differentiation
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: CSV
Series
Accession:
GSE288624
ID:
200288624
7.

Transcriptome Response to Autoantibodies in Human Primary Epidermis Keratinocyte Model for Pemphgus Vulgaris

(Submitter supplied) Pemphigus vulgaris (PV) is an autoimmune disease caused by autoantibodies (AAbs) targeting Desmoglein 1 (DSG1) or Desmoglein 3 (DSG3) on keratinocytes, leading to disrupted cell-cell adhesion and epidermal blistering. To investigate the early signaling events triggered by AAb binding, we examined transcriptomic responses in a human primary epidermis keratinocyte (HPEK) model for PV. After incubating the single-chain variable fragment (scFv) PX43, which targets DSG1 and DSG3, and human IgG as control for 5h, 10h and 24h, differentially expressed genes (DEGs) and regulated pathways was analyzed using DESeq2 and pathway enrichment analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
24 Samples
Download data: XLSX
Series
Accession:
GSE288492
ID:
200288492
8.

TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis

(Submitter supplied) Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling pathways. Here, we have demonstrated that TRPC1 activity is protective within cartilage homeostasis in the prevention of cellular senescence associated cartilage breakdown during mechanical and inflammatory challenge. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
7 Samples
Download data: TSV
Series
Accession:
GSE288320
ID:
200288320
9.

Impact of human anti-O-specific polysaccharide (OSP) antibody on Vibrio cholerae O1 in complex media containing mucin

(Submitter supplied) Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are a main determinant of protection against cholera. These antibodies can agglutinate bacteria, and can also directly inhibit V. cholerae motility, including at sub-agglutinating conditions. In order to evaluate for possible additional impacts of OSP-specific antibody on V. cholerae, we assessed the transcriptional profile of V. more...
Organism:
Vibrio cholerae C6706
Type:
Expression profiling by high throughput sequencing
Platform:
GPL35328
20 Samples
Download data: TXT
Series
Accession:
GSE287993
ID:
200287993
10.

Single cell RNAseq of SOD1 mouse spinal cords

(Submitter supplied) Sequencing was performed to better understand the role of neuroinflammation and glial RIPK1 signaling in ALS pathogenesis in the SOD1G93A transgenic mouse model.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: H5
Series
Accession:
GSE287569
ID:
200287569
11.

Single cell RNAseq of iPSC tri-cultures treated with necroptosis inducer

(Submitter supplied) Transcriptomic analysis of iPSC tri-culture (microglia, neurons, astrocytes) stimulated with Tnf, Smac, and Zvad (TSZ) to trigger necroptosis pathway activation, in the presence or absence of a Ripk1 inhibitor
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
10 Samples
Download data: H5
Series
Accession:
GSE287439
ID:
200287439
12.

Spinal cord single-nuclei RNA sequencing of human ALS spinal cords [ALS human snRNAseq]

(Submitter supplied) Transcriptomic analysis of postmortem cervical spinal cord samples from 8 people with ALS (6 sporadic and 2 familial cases) and 4 age-matched non-neurological controls using snRNA-seq
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: H5
Series
Accession:
GSE287257
ID:
200287257
13.

Bulk RNA sequencing of human ALS spinal cords

(Submitter supplied) There remains a poor understanding of cell-specific responses in the human ALS spinal cord, including differences in cell type composition, changes in cell state, and contribution of various cell types to neuroinflammation.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: CSV
Series
Accession:
GSE287256
ID:
200287256
14.

Regulation of LEAP2 by insulin and glucagon in mice and humans

(Submitter supplied) Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), exhibiting opposing effects on cell signaling, feeding, and hormonal secretion compared to ghrelin. However, despite an emerging interest in LEAP2’s physiology and pharmacology, its endocrine regulation remains unclear. Here, we show that plasma LEAP2 levels decrease significantly upon supraphysiological glucagon infusions during pancreatic somatostatin clamps in humans and that a hypercaloric diet and a sedentary lifestyle for two weeks impair this effect. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
36 Samples
Download data: CSV
Series
Accession:
GSE287171
ID:
200287171
15.

Th1-poised naïve CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease

(Submitter supplied) Naïve CD4 T cells are traditionally viewed as a quiescent, homogeneous, resting population, but merging evidence reveals their heterogeneity, which can be crucial for understanding disease contexts and therapeutic outcomes. In this study, we identify distinct subpopulations within both murine and human naïve CD4 T cells by single cell-RNA-sequencing (scRNA-seq), particularly focusing on a subpopulation that expresses super-high levels of interleukin-7 receptor (IL-7Rsup-hi), along with CD97, IL-18R, and Ly6C. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
6 Samples
Download data: CSV, RESULTS
Series
Accession:
GSE285018
ID:
200285018
16.

Keratinocyte response to PX43-induced split formation under different pathway inhibitions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
136 Samples
Download data
Series
Accession:
GSE285010
ID:
200285010
17.

Mechanistic Investigation of Five Small-Molecule Inhibitors in the Treatment of Pemphigus Vulgaris via RNA-Seq Analysis

(Submitter supplied) Pemphigus vulgaris (PV) is an autoimmune disorder characterized by autoantibodies (AAbs) against Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3) on keratinocytes, resulting in compromised cell-cell adhesion and epidermal blistering. To explore potential therapeutic targets, five small-molecule inhibitors, A66 (PI3Kα inhibitor), BIRB796 (p38 MAPK inhibitor), GW441756 (TrkA inhibitor), Selumetinib (MEK1 inhibitor), and Vandetanib (VEGFR2 inhibitor) were selected through a screen identifying compounds that reduce split formation in a human skin organ culture (HSOC) model. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
34 Samples
Download data: XLSX
Series
Accession:
GSE285009
ID:
200285009
18.

Transcriptome Response and Protein Abundance are Correlated with Split Formation and Cell Detachment as Secondary Effects to Autoantibodies in Human Skin Organ Culture Models for Pemphgus Vulgaris

(Submitter supplied) Pemphigus vulgaris (PV) is an autoimmune disease caused by autoantibodies (AAbs) targeting Desmoglein 1 (DSG1) or Desmoglein 3 (DSG3) on keratinocytes, leading to disrupted cell-cell adhesion and epidermal blistering. To investigate the early signaling events triggered by AAb binding, we examined transcriptomic and proteomic responses in a human skin organ culture (HSOC) model for PV. After injecting the single-chain variable fragment (scFv) PX43, which targets DSG1 and DSG3, or the mouse-derived DSG3 AAb AK23, we quantified transcriptome changes at 0, 5, 10, and 24 hours and proteome responses at 0 and 24 hours, using human or murine IgG as controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
78 Samples
Download data: XLSX
Series
Accession:
GSE285008
ID:
200285008
19.

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species

(Submitter supplied) Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA (mtDNA) mutation rates show accelerated ageing. A scarcely studied aspect of ageing, because it is invisible in aggregate analyses, is the accumulation of somatic mtDNA mutations which are unique to single cells (cryptic mutations). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
12 Samples
Download data: CSV
Series
Accession:
GSE284767
ID:
200284767
20.

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma

(Submitter supplied) The bone marrow microenvironment plays a crucial role in the development of multiple myeloma. As the disease progresses, malignant myeloma cells can evolve to survive outside the bone marrow. However, the processes underlying bone marrow independence and their consequences for immune control remain poorly understood. Here, we conducted single-cell and spatial multi-omics analyses of bone marrow-confined intramedullary disease and paired breakout lesions that disrupt the cortical bone. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL18573 GPL24676
26 Samples
Download data: CSV, JSON, MTX, RDS, TSV, TXT
Series
Accession:
GSE284727
ID:
200284727
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