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Items: 1 to 20 of 453

1.

Serum and Tear Autoantibodies from NOD and NOR Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease [MCF_SSK_546]

(Submitter supplied) Sjögren's Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the protein-rich aqueous component of tears, and SjD-associated autoimmune dacryoadenitis (AD) may thus alter tear autoantibody composition. The presence of tertiary lymphoid structures (TLS) in LG from two murine models of SjD-associated AD, male non-obese diabetic (NOD) and male non-obese insulitis resistant (NOR) mice, were evaluated using immunofluorescence. more...
Organism:
blank sample; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL29507
32 Samples
Download data: GPR, TXT
Series
Accession:
GSE286504
ID:
200286504
2.

Serum Autoantibodies from NOD Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease [IgG_MCF_SH_179]

(Submitter supplied) Male Non-Obese Diabetic (NOD) mice develops autoimmune dacryoadenitis beginning 6-8 weeks of age including lymphocytic infiltration of the lacrimal glands, reduced tear production, increased cysteine tear proteases and restructuring of extracellular membrane structural proteins. Autoantigens with high antibody reactivity in serum of disease model mice may have diagnostic potential for Sjögren's Disease. more...
Organism:
blank sample; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL29507
16 Samples
Download data: GPR, TXT
Series
Accession:
GSE286503
ID:
200286503
3.

Serum and Tear Autoantibodies from NOR Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren's Disease [MCF_SH_292_Slide1_532]

(Submitter supplied) Male Non-Obese Diabetic (NOD) derived NOR mice develop autoimmune dacryoadenitis by 16 weeks of age including lymphocytic infiltration of the lacrimal glands, reduced tear production, and increased cysteine tear proteases. Unlike the NOD mice, the NOR mice do not develop diabetes and studies designed with the NOR mice are expected to not have diabetes development counfounding the results observed for Sjogren's development. more...
Organism:
blank sample; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL29507
16 Samples
Download data: GPR, TXT
Series
Accession:
GSE286502
ID:
200286502
4.

Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension [14 plex]

(Submitter supplied) Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc patients for this potentially fatal complication. In the current study we aimed to characterize specific cytokine signatures that differentiate patients with incident SSc-PAH, patients at high risk for SSc-PAH, patients at low risk for SSc-PAH, and healthy controls. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL31283
182 Samples
Download data: CSV, TXT
Series
Accession:
GSE195583
ID:
200195583
5.

Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension [65-plex]

(Submitter supplied) Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc patients for this potentially fatal complication. In the current study we aimed to characterize specific cytokine signatures that differentiate patients with incident SSc-PAH, patients at high risk for SSc-PAH, patients at low risk for SSc-PAH, and healthy controls. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL31282
182 Samples
Download data: CSV
Series
Accession:
GSE195581
ID:
200195581
6.

Detection of ALDOB expression level in clear cell renal cell carcinoma

(Submitter supplied) Immunohistochemical detection of ALDOB expression levels in clear cell renal cell carcinoma tissues and adjacent normal tissues of 80 patients
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Download data: XLS, XLSX
Series
Accession:
GSE284424
ID:
200284424
7.

Anti-necroptotic effects of human Wharton’s jelly-derived mesenchymal stem cells in skeletal muscle cell death model via secretion of GRO-α

(Submitter supplied) Human mesenchymal stem cells (hMSCs) have therapeutic applications and potential for use in regenerative medicine. However, the use of hMSCs in research and clinical medicine is limited by a lack of information pertaining to their donor-specific functional attributes. In this study, we compared the characteristics of same-donor derived placenta (PL) and Wharton’s jelly (WJ)-derived hMSCs, we also compared their mechanism of action in a skeletal muscle disease in vitro model. more...
Organism:
Mus musculus; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL34899
13 Samples
Download data: GPR
Series
Accession:
GSE277126
ID:
200277126
8.

Targeted immunoproteomics of cerebrospinal fluid in disease-modifying treatment-naïve Multiple Sclerosis patients

(Submitter supplied) We performed a retrospective study on CSF from 20 DMT-naïve MS patients to investigate the correlation between intrathecal immune proteins and clinical MS phenotype.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL30526
20 Samples
Download data: XLSX
Series
Accession:
GSE256426
ID:
200256426
9.

Tlr7 mediates tissue-specific disease manifestations in primary Sjogren’s disease in a sex-biased manner

(Submitter supplied) The goal of this study was to determine whether male and female mice with primary Sjogren's disease (pSD) displayed differences in autoreactive IgM and IgG in sera. We also sought to determine whether this reactivity was dependent on the expression of Tlr7.
Organism:
synthetic construct; Mus; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL34168
64 Samples
Download data: GPR, TXT
Series
Accession:
GSE255215
ID:
200255215
10.

Profiling IgG and IgA antibody responses during vaccination and infection in a population at high risk of gonorrhoea

(Submitter supplied) Development of a vaccine against gonorrhoea is a global priority, driven by the rise in antibiotic resistance and the need to protect against infection and reproductive health consequences. Although Neisseria gonorrhoeae (Ng) infection does not induce substantial protective immunity, there is evidence that highly exposed individuals may develop immunity against re-infection with the same strain. In contrast, retrospective epidemiological studies have shown that immunisation with vaccines containing Neisseria meningitidis (Nm) outer membrane vesicles (OMVs) provides a degree of cross-protection against Ng infection. more...
Organism:
Homo sapiens; Neisseria gonorrhoeae
Type:
Protein profiling by protein array
Platform:
GPL34580
610 Samples
Download data
Series
Accession:
GSE269648
ID:
200269648
11.

Signaling in microglia after anti-PD-1 treatment

(Submitter supplied) In this experiment, we studied how anti-PD-1 effects microglial kinase signaling
Organism:
Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL32056
8 Samples
Download data: TXT
Series
Accession:
GSE225354
ID:
200225354
12.

Deciphering Mycobacterium tuberculosis glycan epitopes through clustering of human polyclonal and isolating novel monoclonal antibodies II

(Submitter supplied) The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. Through isolating and characterizing a panel of novel human mAbs with binding to distinct AM OS motifs, we further defined the glycan epitope structures, identified a new epitope, and determined their differences among mycobacterial strains.
Organism:
Homo sapiens; synthetic construct
Type:
Protein profiling by protein array
Platform:
GPL34369
11 Samples
Download data: GPR, XLSX
Series
Accession:
GSE263497
ID:
200263497
13.

Deciphering Mycobacterium tuberculosis glycan epitopes through clustering of human polyclonal and isolating novel monoclonal antibodies I

(Submitter supplied) The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. We here used synthetic AM oligosaccharide motifs to deplete sera from subjects along the spectrum of Mtb infection. more...
Organism:
Homo sapiens; synthetic construct
Type:
Protein profiling by protein array
Platform:
GPL34369
107 Samples
Download data: GPR, XLSX
Series
Accession:
GSE263496
ID:
200263496
14.

Comparison of novel proteomic expression profiles for radiation exposure in male and female C57BL6 mice

(Submitter supplied) Purpose: There is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. more...
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL34462
148 Samples
Download data: TXT
Series
Accession:
GSE267131
ID:
200267131
15.

Serological autoantibody profiling of emmetropic controls and highly myopic patiens

(Submitter supplied) High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. By using a protein microarray assaying more than 20,000 human proteins, we determined in this study the autoantibody profiles of highly myopic patiens and emmetropic controls.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL33051
72 Samples
Download data: GPR
Series
Accession:
GSE223434
ID:
200223434
16.

An epigenetic gene signature underlies phenotype switching in early stage melanomas.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Protein profiling by protein array; Expression profiling by array
Platforms:
GPL18573 GPL32054 GPL32055
300 Samples
Download data: BW, RCC, SF
Series
Accession:
GSE198432
ID:
200198432
17.

An epigenetic gene signature underlies phenotype switching in early stage melanomas [RPPA]

(Submitter supplied) A 122-epigenetic gene signature distinguished low- versus high-risk early stage melanomas. We sought to validate the signature, examined clinical correlates in a cohort of primary melanomas of the skin, and studied the underlying transcriptomic aberrations and changes in chromatin in cell lines representing these two groups.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32054
15 Samples
Download data
Series
Accession:
GSE198428
ID:
200198428
18.

Serum cytokine and chemokine analysis of patients with treatment-naïve unresectable hepatocellular carcinoma and cancer-free chronic liver disease.

(Submitter supplied) A total of 116 patients, 96 with treatment-naïve unresectable hepatocellular carcinoma (uHCC) and 20 chronic liver disease without any cancer, were analysed for 17 cytokines and chemokines from serum and analysed for oncological features.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL34302
116 Samples
Download data: TXT
Series
Accession:
GSE261672
ID:
200261672
19.

Analysis of DDX39A and DDX56 interacting proteins

(Submitter supplied) DDX39A and DDX56 recombinant proteins were assayed using commercial protein microarrays in order to detect potential interaction partners.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL27459
3 Samples
Download data: GPR
Series
Accession:
GSE150859
ID:
200150859
20.

Impaired innate and adaptive immune responses to BNT162b2 SARSCoV-2 vaccination in systemic lupus erythematosus [CTD]

(Submitter supplied) We measued IgG autoantibodies associated with Connective Tissue Diseases (CTDs) and Anti-Cytokine Antibodies (ACA) in SLE and healthy controls who received the BNT162b2 vaccine.
Organism:
Escherichia coli; Spodoptera frugiperda; Bos taurus; Triticum aestivum; Capra hircus; Homo sapiens; Sus scrofa
Type:
Protein profiling by protein array
Platform:
GPL34257
102 Samples
Download data: TXT, XLSX
Series
Accession:
GSE260478
ID:
200260478
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