Trp53inp2 transformation related protein 53 inducible nuclear protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp53inp2provided by MGI
Official Full Name: transformation related protein 53 inducible nuclear protein 2provided by MGI
Primary source: MGI:MGI:1915978
See related: Ensembl:ENSMUSG00000038375 AllianceGenome:MGI:1915978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tp53inp2; 1110029F20Rik
Summary: Enables ubiquitin binding activity. Acts upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 127.9), heart adult (RPKM 122.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155223742..155231767)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155381811..155389847)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
Title: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
Title: TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
Tp53inp2 is an atypical mRNA that regulates axon growth by enhancing NGF-TrkA signaling in a translation-independent manner.
Title: Regulation of NGF Signaling by an Axonal Untranslated mRNA.
TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity.
Title: TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.
TP53INP2 repression is part of an adaptive mechanism aimed at preserving muscle mass under conditions in which insulin action is deficient.
Title: Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH128655 (e-PCR)
- UniSTS:211963

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tumor protein p53-inducible nuclear protein 2

Names: diabetes and obesity-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418655.1 → NP_001405584.1 tumor protein p53-inducible nuclear protein 2 isoform a

Status: VALIDATED

Source sequence(s)

AL845325

UniProtKB/Swiss-Prot

Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
NM_001418656.1 → NP_001405585.1 tumor protein p53-inducible nuclear protein 2 isoform a

Status: VALIDATED

Source sequence(s)

AL845325

UniProtKB/Swiss-Prot

Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
NM_001418657.1 → NP_001405586.1 tumor protein p53-inducible nuclear protein 2 isoform a

Status: VALIDATED

Source sequence(s)

AL845325

UniProtKB/Swiss-Prot

Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
NM_001418658.1 → NP_001405587.1 tumor protein p53-inducible nuclear protein 2 isoform b

Status: VALIDATED

Source sequence(s)

AL845325

Related

ENSMUSP00000133880.2, ENSMUST00000174685.8
NM_001418659.1 → NP_001405588.1 tumor protein p53-inducible nuclear protein 2 isoform b

Status: VALIDATED

Source sequence(s)

AL845325
NM_001418660.1 → NP_001405589.1 tumor protein p53-inducible nuclear protein 2 isoform c

Status: VALIDATED

Source sequence(s)

AL845325
NM_001418661.1 → NP_001405590.1 tumor protein p53-inducible nuclear protein 2 isoform d

Status: VALIDATED

Source sequence(s)

AL845325
NM_178111.4 → NP_835212.1 tumor protein p53-inducible nuclear protein 2 isoform a

See identical proteins and their annotated locations for NP_835212.1

Status: VALIDATED

Source sequence(s)

AL845325

Consensus CDS

CCDS16947.1

UniProtKB/Swiss-Prot

Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

Related

ENSMUSP00000037627.8, ENSMUST00000043237.14

Conserved Domains (1) summary

pfam14839
Location:28 → 212

DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

155223742..155231767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252040.2 → XP_030107900.1 tumor protein p53-inducible nuclear protein 2 isoform X3

Conserved Domains (1) summary

pfam14839
Location:72 → 217

DOR; DOR family
XM_017319242.2 → XP_017174731.1 tumor protein p53-inducible nuclear protein 2 isoform X3

Conserved Domains (1) summary

pfam14839
Location:72 → 217

DOR; DOR family