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    Ddx3y DEAD box helicase 3, Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 26900, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ddx3yprovided by MGI
    Official Full Name
    DEAD box helicase 3, Y-linkedprovided by MGI
    Primary source
    MGI:MGI:1349406
    See related
    Ensembl:ENSMUSG00000069045 AllianceGenome:MGI:1349406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dby; D1Pas1-rs1; 8030469F12Rik
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in cell differentiation; gamete generation; and negative regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in P granule and nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; liver; lung; and reproductive system. Orthologous to human DDX3Y (DEAD-box helicase 3 Y-linked). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E18 (RPKM 5.2), liver E14.5 (RPKM 4.5) and 17 other tissues See more
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    Genomic context

    See Ddx3y in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1260715..1286630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1260715..1286628, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene ubiquitously transcribed tetratricopeptide repeat containing, Y-linked Neighboring gene predicted gene 4017 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor pseudogene Neighboring gene predicted gene, 25565 Neighboring gene ubiquitin specific peptidase 9, Y chromosome

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX3Y
    Names
    D1Pas1 related sequence 1
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide, Y chromosome
    DEAD box protein 3, Y-chromosomal
    DEAD-box RNA helicase DEAD2
    mDEAD2
    NP_036138.1
    XP_006531666.1
    XP_006531670.1
    XP_011246894.1
    XP_030107428.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012008.2NP_036138.1  ATP-dependent RNA helicase DDX3Y

      See identical proteins and their annotated locations for NP_036138.1

      Status: VALIDATED

      Source sequence(s)
      AJ007376, AK160604, AK162630, BB671323, BC051046, CD552910
      Consensus CDS
      CCDS30543.1
      UniProtKB/Swiss-Prot
      Q62095, Q9QWS9
      UniProtKB/TrEMBL
      Q3U484
      Related
      ENSMUSP00000088729.6, ENSMUST00000091190.12
      Conserved Domains (4) summary
      cd00268
      Location:181403
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:66609
      PTZ00110; helicase; Provisional
      pfam00271
      Location:425535
      Helicase_C; Helicase conserved C-terminal domain
      pfam06273
      Location:87171
      eIF-4B; Plant specific eukaryotic initiation factor 4B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      1260715..1286630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531603.3XP_006531666.1  ATP-dependent RNA helicase DDX3Y isoform X1

      UniProtKB/TrEMBL
      Q3U484
      Conserved Domains (2) summary
      PTZ00110
      Location:66608
      PTZ00110; helicase; Provisional
      cd18051
      Location:159409
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
    2. XM_011248592.4XP_011246894.1  ATP-dependent RNA helicase DDX3Y isoform X2

      UniProtKB/TrEMBL
      Q3U484
      Conserved Domains (2) summary
      PTZ00110
      Location:52595
      PTZ00110; helicase; Provisional
      cd18051
      Location:145395
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
    3. XM_030251568.2XP_030107428.1  ATP-dependent RNA helicase DDX3Y isoform X4

      Conserved Domains (2) summary
      cd18787
      Location:229359
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18051
      Location:1224
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
    4. XM_006531607.5XP_006531670.1  ATP-dependent RNA helicase DDX3Y isoform X3

      Conserved Domains (2) summary
      cd18787
      Location:229359
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd18051
      Location:1224
      DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3