A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

Histone lactylation antagonizes senescence via facilitating gene-expression reprogramming.

Super cChIP-seq, a robust and universal epigenetic profiling method using 10 cells

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion [ATAC-seq]

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming

EZH2 Catalytic Inhibition Prevents Urothelial Carcinoma Progression Through Immune Activation.

Multi-omic analysis of cell-of-origin and epigenomic state in pediatric H3K27M gliomas

Targeting metabolic adaptations in the breast cancer–liver metastatic niche using dietary approaches to improve endocrine therapy efficacy

Phosphorylated MED1 Links Transcription Recycling and Cancer Growth

Rett Syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

The ZMYND8-regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability

Derivation of formative-like pluripotent stem cells from mammalian embryos

H2A.Z Facilitates Licensing and Activation of Early Replication Origins

The p30 isoform of CEBPA uncovers a silent enhancer to drive the expression of the tumor promotive factor CD73 in CEBPA mutant AML

COX-2 mediates tumor-stromal Prolactin signaling to initiate tumorigenesis

Histone demethylase LSD1 is required for germinal center formation and BCL6 driven lymphomagenesis

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

Spliceosome specifically associates with RNA polymerase II CTD Ser5-P isoform to promote co-transcriptional splicing