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| Status |
Public on Nov 08, 2025 |
| Title |
OncoScan CNV Assay (Thermo Fisher Scientific/Affymetrix) data for 13 cold agglutinin disease samples |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
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| Summary |
We analyzed 13 samples of primary cold agglutinin disease (CAD) for copy number variations (CNVs). In 12/13 cases complete or partial trisomy 3/3q was detected. Most of the cases (9/13) had a trisomy 12 or 18 but never both together. 4 cases had trisomy 12 and 5 case had trisomy 18. In addition there were only small recurrent gains and losses. Our data indicate that trisomy 3 or at least +3q is present in almost all cases of CAD and therefore testing for it could aid diagnosis. In addition, trisomy 12 or 18 or absence of it correlates with response to therapy.
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| Overall design |
OncoScan CNV Assay was performed according to the manufacturer's recommendations. DNA was extracted from clonal B-cells sorted from cryopreserved bone marrow or peripheral blood samples using fluorescence activated cell sorting prior to analysis.
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| Contributor(s) |
Trøen G, Małecka A |
| Citation missing |
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| |
| Submission date |
Nov 14, 2019 |
| Last update date |
Nov 08, 2025 |
| Contact name |
Gunhild Trøen |
| Organization name |
Oslo University Hospital
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| Department |
Pathology
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| Street address |
Ullernchausseen 70
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| City |
Oslo |
| ZIP/Postal code |
0379 |
| Country |
Norway |
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| Platforms (1) |
| GPL18602 |
[OncoScan] Affymetrix OncoScan FFPE Assay |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA589634 |
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