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| Status |
Public on Mar 30, 2021 |
| Title |
Transcriptional Response to Dauer-Inducing Ascarosides in Late L1 in C. elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
There are two steps in the C. elegans decision to enter the dauer-diapause lifestage. The first is a choice between L2 and L2d and the second is between L3 and dauer. We studied the transcriptional changes when well-fed worms were given a cocktail of dauer-inducing ascarosides in the late L1 phase as opposed to worms that received no such treatment. This study was done in both N2 wild-type worms, and daf-22 worms, which lack an enzyme necessary to produce endogenous ascarosides.
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| |
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| Overall design |
Transcriptional response of late L1 stage worms to a cocktail of ascr#2, ascr#3, and ascr#8 in in both N2 and daf-22 backgrounds.
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| |
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| Contributor(s) |
Cohen SM, Sun JJ, Schroeder FC, Sternberg PW |
| Citation(s) |
33997661 |
| |
| Submission date |
Mar 29, 2021 |
| Last update date |
May 17, 2021 |
| Contact name |
Sarah Cohen |
| E-mail(s) |
scohen@caltech.edu
|
| Phone |
6144407272
|
| Organization name |
California Institute of Technology
|
| Department |
Biology and Bioengineering
|
| Lab |
Sternberg
|
| Street address |
257 S. Hudson Ave, Unit 108
|
| City |
Pasadena |
| State/province |
CA |
| ZIP/Postal code |
91101 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18245 |
Illumina HiSeq 2500 (Caenorhabditis elegans) |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA718306 |
| SRA |
SRP312615 |
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