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| Status |
Public on Nov 13, 2025 |
| Title |
Immune-Epithelial Interactions and Tissue Remodeling in the Inflammatory Respiratory Nasal Tract [scRNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Chronic rhinosinusitis (CRS) is a common inflammatory disease of the nasal cavity and sinuses that affects millions of individuals worldwide. The complex pathophysiology of CRS remains poorly understood, with emerging evidence implicating diverse immune and epithelial cell types in the disease process. We employed single-cell RNA sequencing (scRNA-seq) in dissociated tissues to investigate the cellular and molecular heterogeneity of CRS with and without nasal polyps.
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| Overall design |
Samples from patients with CRS with and without nasal polyps and healthy controls were collected and analyzed using single-cell RNA sequencing (scRNA-seq).
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| Contributor(s) |
Nayak JV |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jun 23, 2023 |
| Last update date |
Nov 14, 2025 |
| Contact name |
Guanrui Liao |
| E-mail(s) |
haixuanliao@gmail.com
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| Organization name |
BIDMC
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| Street address |
3 Blackfan Circle
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| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (20)
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| GSM7508292 |
Control_4, Ethmoid sinus, scRNAseq |
| GSM7508293 |
Control_5, Ethmoid sinus, scRNAseq |
| GSM7508294 |
CRSsNP_Eth_1, Ethmoid sinus, scRNAseq |
| GSM7508295 |
CRSsNP_Eth_2, Ethmoid sinus, scRNAseq |
| GSM7508296 |
CRSsNP_Eth_3, Ethmoid sinus, scRNAseq |
| GSM7508297 |
CRSsNP_Eth_4, Ethmoid sinus, scRNAseq |
| GSM7508298 |
CRSsNP_Eth_5, Ethmoid sinus, scRNAseq |
| GSM7508299 |
CRSwNP_Eth_1, Ethmoid sinus, scRNAseq |
| GSM7508300 |
CRSwNP_Eth_2, Ethmoid sinus, scRNAseq |
| GSM7508301 |
CRSwNP_Eth_3, Ethmoid sinus, scRNAseq |
| GSM7508302 |
CRSwNP_Eth_6, Ethmoid sinus, scRNAseq |
| GSM7508303 |
CRSwNP_NP_1, Nasal polyps, scRNAseq |
| GSM7508304 |
CRSwNP_NP_2, Nasal polyps, scRNAseq |
| GSM7508305 |
CRSwNP_NP_3, Nasal polyps, scRNAseq |
| GSM7508306 |
CRSwNP_Eth_4, Ethmoid sinus, scRNAseq |
| GSM7508307 |
CRSwNP_Eth_5, Ethmoid sinus, scRNAseq |
| GSM7508308 |
CRSwNP_NP_6, Nasal polyps, scRNAseq |
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| This SubSeries is part of SuperSeries: |
| GSE235715 |
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation |
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| Relations |
| BioProject |
PRJNA986941 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE235711_RAW.tar |
552.8 Mb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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