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| Status |
Public on Jul 15, 2025 |
| Title |
Genomic profiles of oxidative stress-induced renal cell carcinomas developed in wild-type and BRCA2+/- SD rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Genome variation profiling by array
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| Summary |
Fenton reaction-based repeated oxidative stress via ferric nitrilotriacetate (Fe-NTA) causes renal cell carcinoma (RCC) with genetic alterations similar to those in humans. We conducted high-resolution microarray comparative genomic hybridization with Fe-NTA induced RCC obtained from both wild-type and BRCA2+/- rats to evaluate the involvement of BRCA2 haploinsufficiency in carcinogenesis.
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| Overall design |
The carcinogenesis protocol was started with 28 wildtype and 22 BRCA2+/- male Jcl: SD rats. 37 rats developed a renal cell carcinoma in total. Genomes of 8 samples from RCCs for each genotype (16 in total) were profiled on Agilent 180K rat genome CGH microarrays.
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| Contributor(s) |
Maeda Y, Akatsuka S, Motooka Y, Toyokuni S |
| Citation(s) |
40609478 |
| |
| Submission date |
Jan 29, 2025 |
| Last update date |
Jul 16, 2025 |
| Contact name |
Shinya Toyokuni |
| E-mail(s) |
akatsuka@med.nagoya-u.ac.jp
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| Organization name |
Nagoya University
|
| Department |
Pathology
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| Street address |
65 Tsuruma-Cho, Showa-Ku
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| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL10451 |
Agilent-027064 SurePrint G3 Rat CGH Microarray 4x180K |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA1216916 |
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