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| Status |
Public on Dec 14, 2025 |
| Title |
Cancer cells transfer invasive properties through microRNAs contained in collagen-tracks |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Invasion is a prerequisite for metastasis formation. During tumor development, type I collagen overexpression increases tumor microenvironment stiffness, facilitating cancer cell dissemination. During breast cancer cell migration in 2D and 3D matrices, we observed membrane debris left behind, attached to the collagen fibrils, along the migration path. We named these structures collagen-tracks. Their formation is stimulated by the interaction between the extracellular matrix (ECM) and matrix receptors, such as the discoidin-domain receptor 1 (DDR1). They present a specific nucleic acid and protein contents. When deposited by highly invasive breast cancer cells, internalized collagen-tracks reprogram non-invasive cells into highly pro-metastatic ones by inducing a partial epithelial–mesenchymal transition (EMT) associated with an increase in ECM degradation and cell invasiveness. This cell reprogramming is dependent on specific miRNAs identified in the collagen-tracks. Collagen-tracks thus represent a new form of cell-cell communication important for driving tumor invasion that could be targeted to prevent metastasis.
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| Overall design |
RNA-seq profiling of MCF7 (WT) on collagen and MCF7 with collagen-tracks on collagen after 72H
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| Web link |
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01497-4
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| Contributor(s) |
Saltel F, Rouyer L, Normand L, Richard E, Allain N, Giraud J, Di-Tommaso S, Raymond A, Dourthe C, Dupuy J, Moreau K, Iggo R, Dugot-Senant N, MacGrogan G, Bouter A, Tan S, Favereaux A, Moreau V, Luco R, Ros M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 23, 2025 |
| Last update date |
Dec 14, 2025 |
| Contact name |
Kevin MOREAU |
| E-mail(s) |
kevinmoreau001@gmail.com
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| Organization name |
CNRS
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| Street address |
Rue Henri Becquerel – CS 90030
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| City |
Orsay |
| ZIP/Postal code |
91401 |
| Country |
France |
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| Platforms (1) |
| GPL34281 |
Illumina NovaSeq X (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1333344 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE308896_tablecounts_raw.csv.gz |
538.9 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
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