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| Status |
Public on Dec 14, 2025 |
| Title |
Fat mass and obesity-associated (FTO)/SOCS6-m⁶A axis epigenetic modification links obesity to atopic dermatitis by regulating keratinocyte function |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Atopic dermatitis is one of the severe skin diseases. Keratinocytes, as the epidermal barrier cells, are an important component for maintaining the skin barrier function. In this dataset, we have included the m⁶A methylation RNA data obtained from normal human keratinocytes (N group) and keratinocytes from patients with atopic dermatitis (AD group).
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| Overall design |
We generated the following comparisons using Fold-change (FC) ≥ 1.5 or ≤ 0.5, and p < 0.05 were used to identify the differentially m6A methylated RNAs.The total RNAs were immunoprecipitated with anti-N6-methyadenosine (m6A) antibody. The modified RNAs were eluted from the immunoprecipitated magnetic beads as the “IP”. The unmodified RNAs were recovered from the supernatant as “Sup”. Two channel arrays were used for these samples but the data were analyzed as single-channel so that each sample represents either IP or supernatent and the sample table includes the normalized signal values.
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| Contributor(s) |
Xiao F, Zeng J |
| Citation missing |
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| Submission date |
Dec 01, 2025 |
| Last update date |
Dec 15, 2025 |
| Contact name |
Zeng Jinrong |
| E-mail(s) |
zengjinrong1989@csu.edu.cn
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| Organization name |
the Third Xiangya Hospital, Central South University
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| Street address |
No.138 Tongzipo Rd, Yuelu District, Changsha, Hunan, China, 410013
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| City |
Changsha |
| ZIP/Postal code |
410013 |
| Country |
China |
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| Platforms (1) |
| GPL25759 |
Agilent-085753 Arraystar Human Epitranscriptomic microarray |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1372119 |
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