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| Status |
Public on Jul 09, 2015 |
| Title |
Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
KMS-11 and KMS-34 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell cultures, denoted KMS-11/Cfz and KMS-34/Cfz, respectively, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.
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| Overall design |
KMS-11/Cfz and KMS-34/Cfz cells were profiled for gene expression after 1 week of growth in the absence of carfilzomib together with parental KMS-11 and KMS-34 cells which had not been selected in the drug (triplicate samples).
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| Contributor(s) |
Riz I, Hawley TS, Hawley RG |
| Citation(s) |
26109433 |
| |
| Submission date |
May 20, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Robert Hawley |
| Organization name |
George Washington University
|
| Department |
Anatomy and Regenerative Biology
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| Street address |
2300 I Street NW, Suite 431
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| City |
Washington |
| State/province |
DC |
| ZIP/Postal code |
20037 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA284490 |
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