|
| Status |
Public on Jul 26, 2017 |
| Title |
Transgenerational inheritance of mitochondrial stress adaptation in C. elegans |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Using Caenorhabditis elegans to investigate environmental cues-induced mitochondrial dysfunction, we found that exposure to electron transport chain (ETC) inhibitors at the parental generation initiates the transmission of heritable information to descendants and make descendants stress-adaptive. This mitochondrial stress adaptation phenotype can persist for at least three generations. Animals lacking histone H3K4me3 chromatin modifiers, or the methyltransferase of N6-methyldeoxyadenosine (6mA), lose the ability to initiate stress adaptation in progeny. H3K4me3 plays a role upstream of 6mA, while both mark promoter regions of mitochondrial unfolded protein response (UPR mt ) genes and activate the UPR mt pathway to alleviate mitochondrial damage.
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| Overall design |
Profile H3K4me3 occupancy in whole body from L3-L4 mix C. elegans, worms were treated with antimycin A (AA) or not treated (NT).
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| Contributor(s) |
Ma C, Niu R, Shao L, Peng Y, Wang Y, Jia G, He A, He C, Liu Y |
| Citation missing |
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| |
| Submission date |
Aug 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Yong Peng |
| E-mail(s) |
yongp@outlook.com
|
| Organization name |
University of Chicago
|
| Department |
Department of Chemistry
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| Lab |
Chuan He
|
| Street address |
929 E 57th Street
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60615 |
| Country |
USA |
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| Platforms (1) |
| GPL18245 |
Illumina HiSeq 2500 (Caenorhabditis elegans) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA339523 |
| SRA |
SRP082400 |
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