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Status |
Public on Jul 31, 2019 |
Title |
A compendium of promoter-centered long-range chromatin interactions in diverse human tissues and cell types |
Organism |
Homo sapiens |
Experiment type |
Other
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Summary |
A large number of genetic variants associated with human diseases are found in non-coding DNA and may contribute to illness by affecting gene regulation, but mechanistic study of these variants has been hindered by a lack of information of their potential regulatory targets. In order to overcome this limitation, we generate maps of long-range chromatin interactions centered on 19,539 promoters in 27 human cell/tissue types, and use this information to infer putative target genes of candidate cis-regulatory sequences throughout the human genome. In additional to known enhancer-promoter interactions, we also confirm widespread promoter-promoter interactions and obtain evidence suggesting enhancer-like function for many promoter regions. These promoter-centered chromatin interaction maps corroborate target genes of genetic variants defined in previous genome-wide association studies, predict new target genes of many disease-associated genetic variants, and contribute novel insights into a broad spectrum of human traits and diseases.
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Overall design |
The study contains promoter capture Hi-C results for diverse human cell/tissue types .bz2, text files for promoter capture Hi-C chromatin interaction between DNA fragments for promoter-promoter interactions (PP) or promoter-other interactions (PO) pp: P-P interaction frequency po: P-O interaction frequency
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Web link |
http://www.3div.kr/capture_hic
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Contributor(s) |
Jung I, Schmitt A, Lee A, Ren B |
Citation(s) |
31501517 |
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Submission date |
Aug 29, 2016 |
Last update date |
Dec 05, 2019 |
Contact name |
Inkyung Jung |
E-mail(s) |
ijungkaist@gmail.com
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Organization name |
KAIST
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Department |
Biological Sciences
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Street address |
KAIST, 291 Daehak-ro, Yuseong-gu
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City |
Daejeon |
ZIP/Postal code |
34141 |
Country |
South Korea |
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Platforms (3) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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Samples (249)
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Relations |
BioProject |
PRJNA340778 |
SRA |
SRP083285 |