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Status |
Public on Jul 01, 2018 |
Title |
Ribosome profiling of G2019S LRRK2 human dopamine neurons |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing Other
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Summary |
G2019S mutaion of LRRK2 is known to increase mRNA translation. We perform ribosome profiling to study defective translation using human dopamine neuron models. Patient-derived human dopamine neurons with G2019S LRRK2 mutation were generated and used. Also a mutation-corrected isogenic pair line was used.
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Overall design |
hDA neurons: 60 days old samples were used.
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Contributor(s) |
Kim J, Dawson TM, Dawson VL |
Citation missing |
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NIH grant(s) |
Grant ID |
Grant title |
Affiliation |
Name |
P50 NS038377 |
LRRK2 Biology in Parkinson's Disease |
JOHNS HOPKINS UNIVERSITY |
VALINA L. DAWSON |
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Submission date |
Nov 23, 2016 |
Last update date |
Aug 17, 2020 |
Contact name |
Jungwoo Wren Kim |
E-mail(s) |
jwrenkim@berkeley.edu, jwk0906@gmail.com
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Organization name |
UC Berkeley
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Department |
Molecular and Cell Biology
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Lab |
Ingolia Lab
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Street address |
Barker Hall, Room 416
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City |
Berkeley |
State/province |
CA |
ZIP/Postal code |
94720 |
Country |
USA |
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Platforms (2) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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Samples (20)
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Relations |
BioProject |
PRJNA354729 |
SRA |
SRP093833 |