NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE90469 Query DataSets for GSE90469
Status Public on Jul 01, 2018
Title Ribosome profiling of G2019S LRRK2 human dopamine neurons
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Other
Summary G2019S mutaion of LRRK2 is known to increase mRNA translation. We perform ribosome profiling to study defective translation using human dopamine neuron models. Patient-derived human dopamine neurons with G2019S LRRK2 mutation were generated and used. Also a mutation-corrected isogenic pair line was used.
 
Overall design hDA neurons: 60 days old samples were used.
 
Contributor(s) Kim J, Dawson TM, Dawson VL
Citation missing Has this study been published? Please login to update or notify GEO.
NIH grant(s)
Grant ID Grant title Affiliation Name
P50 NS038377 LRRK2 Biology in Parkinson's Disease JOHNS HOPKINS UNIVERSITY VALINA L. DAWSON
Submission date Nov 23, 2016
Last update date Aug 17, 2020
Contact name Jungwoo Wren Kim
E-mail(s) jwrenkim@berkeley.edu, jwk0906@gmail.com
Organization name UC Berkeley
Department Molecular and Cell Biology
Lab Ingolia Lab
Street address Barker Hall, Room 416
City Berkeley
State/province CA
ZIP/Postal code 94720
Country USA
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (20)
GSM2402496 SC1014_ribo
GSM2402497 SC1015_ribo
GSM2402498 SC1055_ribo
Relations
BioProject PRJNA354729
SRA SRP093833

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90469_hDA.txt.gz 1.0 Mb (ftp)(http) TXT
GSE90469_hDA_TE.csv.gz 932.6 Kb (ftp)(http) CSV
GSE90469_hDA_mRNA.csv.gz 1012.6 Kb (ftp)(http) CSV
GSE90469_hDA_ribo.csv.gz 938.0 Kb (ftp)(http) CSV
GSE90469_iso_hDA_TE.csv.gz 845.5 Kb (ftp)(http) CSV
GSE90469_iso_hDA_mRNA.csv.gz 930.6 Kb (ftp)(http) CSV
GSE90469_iso_hDA_ribo.csv.gz 929.0 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap