txid3052230[Organism:exp] - PubChem BioAssay - NCBI

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Select item 19599161.

Inhibition of HCV RNA IRES IIa by FRET assay

Source:: ChEMBL

Assay data:3 Tested

AID:: 1959916

Select item 19591812.

Inhibition of Hepatitis C virus NS5B polymerase

Source:: ChEMBL

Protein Target:: RNA-directed RNA polymerase

Assay data:2 Active, 6 Tested

AID:: 1959181

Summary Related BioAssays by Target

Select item 19571643.

Antiviral activity against Hepatitis C virus subtype 1b infected in Huh-7 cells transfected with HCV subgenomic replicon for NS5B polymerase assessed as inhibition of viral replication measured upto 96 hrs in presence of 40% of human serum by luciferase reporter gene assay

Source:: ChEMBL

Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested

AID:: 1957164

Select item 19571634.

Antiviral activity against Hepatitis C virus subtype 1b infected in Huh-7 cells transfected with HCV subgenomic replicon for NS5B polymerase assessed as inhibition of viral replication measured upto 96 hrs by luciferase reporter gene assay

Source:: ChEMBL

Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested

AID:: 1957163

Select item 19544095.

Binding affinity to HCV IRES

Source:: ChEMBL

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1954409

Select item 19544026.

Binding affinity to HCV RNA

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1954402

Select item 19538177.

Inhibition of Hepatitis C virus NS5B polymerase

Source:: ChEMBL

Assay data:5 Tested

AID:: 1953817

Select item 19538148.

Antiviral activity against HCV subtype 1b in Huh-5-2 cells

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1953814

Select item 19538139.

Antiviral activity against HCV assessed as inhibition of HCV RNA replication at 5.0 uM relative to control

Source:: ChEMBL

Assay data:1 Tested

AID:: 1953813

Select item 195381210.

Antiviral activity against HCV assessed as inhibition of RNA replication

Source:: ChEMBL

Assay data:2 Active, 3 Tested

AID:: 1953812

Select item 194977311.

Antiviral activity against HCV GT1b-genotype assessed as viral growth inhibition measured after 24 hrs

Source:: ChEMBL

Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested

AID:: 1949773

Select item 194977012.

Inhibition of Hepatitis C virus genotype 6a NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949770

Select item 194976913.

Inhibition of Hepatitis C virus genotype 5a NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949769

Select item 194976814.

Inhibition of Hepatitis C virus genotype 4a NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949768

Select item 194976715.

Inhibition of Hepatitis C virus genotype 3a NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949767

Select item 194976616.

Inhibition of Hepatitis C virus genotype 2b NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949766

Select item 194976517.

Inhibition of Hepatitis C virus genotype 2a NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949765

Select item 194976418.

Inhibition of Hepatitis C virus genotype 1b NS3/NS4A protease

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949764

Select item 194976319.

Antiviral activity against HCV GT-2a assessed as inhibition of viral replication measured after 24 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949763

Select item 194976220.

Antiviral activity against HCV GT1b-genotype assessed as inhibition of viral replication measured after 24 hrs

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1949762

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Proteins (549)
BioAssays with protein sequences specified as targets

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Chemical Probes (3)
BioAssays with compounds reported as validated chemical probes

Active Compounds (3,153)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (773)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (2,504)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (3,165)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (11)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (38)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (4,845)
BioAssays extracted from the literature
NIH MLP (38)
BioAssays deposited by the NIH Molecular Libraries Program
Other (28)
BioAssays deposited by other experimentalists

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