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Drug metabolism in monkey intestinal microsomes assessed as rate of metabolism
Assay data:1 Tested
Summary
Stability in monkey liver microsomes assessed as half life
Assay data:2 Tested
Antiplatelet aggregation activity in rhesus monkey platelet rich plasma assessed as reduction in collagen-induced platelet aggregation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiplatelet aggregation activity in rhesus monkey platelet rich plasma assessed as reduction in ADP-induced platelet aggregation
Inhibition of rhesus monkey blood platelet aggregation at 1 mg/kg, po
Inhibition of Rhesus monkey blood platelet aggregation at 4 mg/kg, po
Drug uptake in iv dosed monkey brain assessed as standardized uptake value after 90 mins by PET imaging analysis
Stability in monkey plasma assessed as compound remaining at 40 uM incubated for 6 hrs
Assay data:1 Active, 1 Tested
Stability in monkey plasma assessed as compound remaining at 1 uM incubated for 6 hrs
Stability in monkey hepatocyte assessed as compound remaining at 3 uM incubated upto 120 mins
Drug metabolism in monkey hepatocytes assessed as docetaxel metabolite formation at 20 uM incubated for 180 mins
Drug metabolism in monkey hepatocytes assessed as MDA-205 metabolite formation at 20 uM incubated for 180 mins
Ocular toxicity in monkey at 10 ug/ml
Ocular toxicity in monkey assessed as aqueous cells and aqueous flare at 1000 ug/ml, post single dose administration after 6 hrs
Ocular toxicity in monkey at 1000 ug/ml post single dose administration after 48 hrs
Toxicity in monkey assessed as NOAEL after 8 weeks
Metabolic stability in monkey liver microsomes assessed as intrinsic clearance
Metabolic stability in monkey liver microsomes assessed as half life
Bioavailability in monkey
Terminal half-life in rhesus monkey at 40 mg/kg, po
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