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Binding affinity to RIPK1 (unknown origin) assessed as dissociation constant by kinomescan assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
RIPK1-ADP-Glo Enzymatic Assay from US Patent US20240025912: "RIPK1 INHIBITORS AND METHODS OF USE"
Assay data:108 Active, 108 Activity ≤ 1 µM, 108 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
RIPK1 Kinase Activity Assay from US Patent US20240002388: "PYRIMIDINONE COMPOUNDS AND USES THEREOF"
Assay data:78 Active, 78 Activity ≤ 1 µM, 78 Tested
In Vitro Kinase Assay from US Patent US20230365546: "5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF"
Assay data:182 Active, 7 Activity ≤ 1 nM, 212 Activity ≤ 1 µM, 212 Tested
RIPK1 Binding Assay from US Patent US11767310: "Nicotinamide RIPK1 inhibitors"
Assay data:17 Active, 17 Activity ≤ 1 µM, 18 Tested
ADP-Glo Kinase Assay from US Patent US11718612: "Inhibitors of receptor interacting protein kinase I for the treatment of disease"
Assay data:59 Active, 37 Activity ≤ 1 µM, 70 Tested
ADP-Glo Kinase Assay from US Patent US11690850: "Inhibitors of receptor interacting protein kinase I for the treatment of disease"
Assay data:81 Active, 44 Activity ≤ 1 µM, 101 Tested
Biochemical Assay using the ADP-Glo from US Patent US11667643: "RIP1K inhibitors"
Assay data:77 Active, 67 Activity ≤ 1 µM, 80 Tested
RIPK1 HTRF Binding Assay from US Patent US11618753: "Aminopyrrolotriazines as kinase inhibitors"
Assay data:687 Active, 4 Activity ≤ 1 µM, 1532 Tested
Enzyme Assay from US Patent US11607396: "Bicyclic amide compounds and methods of use thereof"
Assay data:104 Active, 75 Activity ≤ 1 µM, 106 Tested
Kinase Inhibition Assay from US Patent US11584758: "RIP1K inhibitors"
Assay data:56 Active, 52 Activity ≤ 1 µM, 57 Tested
Biochemical Assay from US Patent US11578078: "Heterocyclic RIP1 inhibitory compounds"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Biochemical Assay from US Patent US11564930: "RIP1 inhibitory compounds and methods for making and using the same"
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000339a RIPK1
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000335a RIPK1
Affinity Biochemical interaction (TR-FRET binding assay (Invitrogen)) EUB0000720a RIPK1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (TR-FRET binding assay (Invitrogen)) EUB0000719a RIPK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Phenotypic Cellular interaction (CytoTox 96 nonradioactive cytotoxicity assay (necroptosis in HT29 cells; Promega)) EUB0000720a RIPK1
Affinity Phenotypic Cellular interaction (CytoTox 96 nonradioactive cytotoxicity assay (necroptosis in HT29 cells; Promega)) EUB0000719a RIPK1
Inhibition of human RIP1
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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