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Determination of Related Protease Inhibition from US Patent US20240059691: "ENZYME INHIBITORS"
Assay data:279 Active, 16 Activity ≤ 1 nM, 253 Activity ≤ 1 µM, 299 Tested
SummaryRelated BioAssays by Target
Inhibition of Kallikrein in human plasma at 500 uM by chromogenic substrate hydrolysis assay
Assay data:27 Tested
Inhibition of human plasma kallikrein at 5 uM using Z-FR-MCA as substrate relative to control
Assay data:2 Tested
Inhibition of human plasma kallikrein using Z-FR-MCA as substrate
Assay data:3 Tested
Inhibition of human plasma kallikrein usingPro-Phe-Arg-AMC as substrate incubated for 5 mins
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-p-nitroaniline as substrate assessed as inhibition constant
Assay data:15 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 17 Tested
Inhibition of human plasma kallikrein using H-DPro-Phe-Arg-AFC as substrate
Assay data:8 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of human plasma kallikrein incubated for 1 hrs
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of rat recombinant plasma kallikrein using Z-FR-AMC as substrate assessed as inhibition constant by fluorescence plate reader analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of plasma kallikrein (unknown origin)
Assay data:13 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of human factor 11a using GPR-AFC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence based analysis
Assay data:10 Active, 10 Tested
Inhibition of human plasma kallikrein using Acetyl-K- P-R-AFC as substrate by fluorescence based analysis
Assay data:10 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Biochemical Assay from US Patent US11884660: "Substituted oxopyridine derivative"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Activity of Exemplary Compounds Against Plasma Kallikrein from US Patent US11787796: "Plasma Kallikrein inhibitors and uses thereof"
Assay data:134 Active, 39 Activity ≤ 1 nM, 94 Activity ≤ 1 µM, 150 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kallikrein Assay from US Patent US20230286958: "PLASMA KALLIKREIN INHIBITORS"
Assay data:185 Active, 65 Activity ≤ 1 nM, 183 Activity ≤ 1 µM, 185 Tested
Plasma Kallikrein Activity Assay from US Patent US11708332: "Human plasma kallikrein inhibitors"
Assay data:168 Active, 250 Activity ≤ 1 µM, 250 Tested
Plasma Kallikrein Activity Assay from US Patent US11685721: "Human plasma kallikrein inhibitors"
Assay data:164 Active, 245 Activity ≤ 1 µM, 245 Tested
Determination of the IC50 for Plasma Kallikrein from US Patent US11613527: "Enzyme inhibitors"
Assay data:116 Active, 116 Activity ≤ 1 µM, 116 Tested
Biological Assay from US Patent US11584735: "Solid forms of a plasma kallikrein inhibitor and salts thereof"
Inhibition of endogenous human plasma kallikrein using Z-Phe-Arg-AMC.HCl as substrate measured after 5 mins by microplate reader analysis
Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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