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In Vitro JAK Kinase Assay from US Patent US20240058343: "TREATMENT OF URTICARIA USING JAK INHIBITORS"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
SummaryRelated BioAssays by Target
NanoBRET assay (JAK1, SGC Frankfurt)
Assay data:2 Tested
Inhibition of JAK1 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
Assay data:1 Tested
Inhibition of JAK1/3 dependent IL-2 stimulated STAT5 phosphorylation in CD3-positive T cells (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of JAK1 JH2 (unknown origin) at 10 uM by DiscoverX KINOMEscan relative to control
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1 (unknown origin) by Ambit kinase assay
Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15 stimulation for 15 mins by flow cytometry method
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of GST-fused JAK1 (866 to 1154 residues) (unknown origin) using FITC-AhxKKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimulation for 15 mins by flow cytometry method
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation for 15 mins by flow cytometry method
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of JAK1 (unknown origin)
Inhibition of JAK1 (unknown origin) assessed as inhibition constant
Competitive inhibition of JAK1 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assay
Inhibition of human JAK1 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysis
Inhibition of recombinant JAK1 (unknown origin) in the presence of ATP
Competitive inhibition of JAK1 (unknown origin) in the presence of ATP
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of recombinant GST-tagged JAK1 (unknown origin) expressed in baculovirus infected Sf9 cells in the presence of ATP by Alphascreen assay
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