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TBD from US Patent US20240059694: "COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF"
Assay data:28 Active, 30 Activity ≤ 1 µM, 30 Tested
SummaryRelated BioAssays by Target
Inhibition of JAK3 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Assay data:1 Tested
Inhibition of JAK3 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control
Inhibition of JAK3 (unknown origin)
Assay data:10 Activity ≤ 1 µM, 10 Tested
Inhibition of human JAK3 assessed as residual activity at 1 uM relative to control
Inhibition of JAK3 (unknown origin) at 1 uM relative to control
Inhibition of JAK3 (unknown origin) by Z'LYTE assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of JAK3 (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of JAK1/3 dependent IL-2 stimulated STAT5 phosphorylation in CD3-positive T cells (unknown origin)
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK3 (unknown origin) by Ambit kinase assay
Assay data:3 Tested
Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15 stimulation for 15 mins by flow cytometry method
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of GST-fused JAK3 (811 to 1124 residues) (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimulation for 15 mins by flow cytometry method
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of human JAK3 preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay
Inhibition of JAK3 (unknown origin) incubated for 20 mins
Inhibition of JAK3 (unknown origin) assessed as dissociation constant in the presence of [gamma p33]-ATP by radiometric assay
Competitive inhibition of JAK3 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assay
Inhibition of human JAK3 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysis
Inhibition of JAK3 (unknown origin) by Lanthascreen kinase assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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