Neuroblastoma cells NG108 exposed to a physiological dose (4400 ng/ml) of antimalarial mefloquine (Lariam), or 0.25% DMSO (control), for 2 hours. Mefloquine appears to disrupt neuronal function through disrupted calcium homeostasis and ER stress.
GPL89:
[RT_U34] Affymetrix Rat Toxicology U34 Array
Citation:
Dow GS. Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine. Malar J 2003 Feb 27;2:4. PMID: 12675948
