Analysis of livers from males fed a high polyunsaturated diet containing 70% corn oil to induce the development of non-alcoholic steatohepatitis (NASH). In NASH, steatosis is accompanied by inflammation, necrosis, apoptosis, and fibrosis. Results provide insight into the pathogenesis of NASH.
Baumgardner JN, Shankar K, Hennings L, Badger TM et al. A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. Am J Physiol Gastrointest Liver Physiol 2008 Jan;294(1):G27-38. PMID: 17947452
