Interleukin-1α deficiency effect on injured spinal cord
Summary:
Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.
Bastien D, Bellver Landete V, Lessard M, Vallières N et al. IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3. J Neurosci 2015 Jul 29;35(30):10715-30. PMID: 26224856
