GEO DataSets

(Submitter supplied) HP1 alpha, beta, and gamma play an evolutionarily conserved role in the formation and maintenance of heterochromatin. In addition, some HP1 family members may also participate in transcriptional regulation of genes. Recently, HP1 gamma binding to the bodies of a subset of genes has been observed in human and murine cells. However, the generality of this phenomenon and the role HP1 gamma may play in this context are unknown. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

8 related Platforms

39 Samples

Download data: BED, BEDGRAPH, GFF, GPR, PAIR

(Submitter supplied) The cyclin-dependent kinase inhibitor p16INK4a (CDKN2A) is an important tumor-suppressor gene frequently inactivated in human tumors. p16 suppresses the development of cancer by triggering an irreversible arrest of cell proliferation termed cellular senescence. Here, we describe another anti-oncogenic function of p16 in addition to its ability to halt cell cycle progression. We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, in both normal and malignant breast epithelial cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

27 Samples

Download data: GPR

(Submitter supplied) The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed an experimental strategy for comprehensive determination of such functional elements in human DNA. This strategy involves the application of genome-wide location analysis, also known as ChIP-chip, to a panel of well-characterized regulatory proteins and histones with specific modifications, known to generally associate with transcriptional regulatory elements in vivo. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

15 Samples

Download data: GPR

(Submitter supplied) The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed an experimental strategy for comprehensive determination of such functional elements in human DNA. This strategy involves the application of genome-wide location analysis, also known as ChIP-chip, to a panel of well-characterized regulatory proteins and histones with specific modifications, known to generally associate with transcriptional regulatory elements in vivo. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL1454 GPL4559

51 Samples

Download data: GPR, PAIR

(Submitter supplied) The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed an experimental strategy for comprehensive determination of such functional elements in human DNA. This strategy involves the application of genome-wide location analysis, also known as ChIP-chip, to a panel of well-characterized regulatory proteins and histones with specific modifications, known to generally associate with transcriptional regulatory elements in vivo. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL1454 GPL4559

124 Samples

Download data: GPR, PAIR

(Submitter supplied) The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed an experimental strategy for comprehensive determination of such functional elements in human DNA. This strategy involves the application of genome-wide location analysis, also known as ChIP-chip, to a panel of well-characterized regulatory proteins and histones with specific modifications, known to generally associate with transcriptional regulatory elements in vivo. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

24 Samples

Download data

(Submitter supplied) Eukaryotic gene regulatory information is contained within the DNA sequences of cis-regulatory elements and the epigenetic features of the chromatin surrounding these elements. Recent investigations in yeast, fly, and mammalian systems have made significant contributions toward our understanding of the relationship between gene activation and chromatin architecture at transcriptional promoters, but much work remains to improve our knowledge of this relationship at human promoters and other transcriptional regulatory elements, such as enhancers. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL4558 GPL1454 GPL4559

64 Samples

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(Submitter supplied) Insulators are an important class of transcriptional regulatory sequences that affect gene expression by preventing the spread of heterochromatin and restricting how transcriptional enhancers select their target genes. The vertebrate insulators function by interacting with the CCCTC-binding factor (CTCF), an evolutionarily conserved DNA binding protein. Knowledge of the CTCF binding sites in the human genome is crucial for identifying potential insulators and understanding the role of these elements in regulating genome expression in the human cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

40 related Platforms

42 Samples

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(Submitter supplied) Genome-wide location analysis of SUZ12 and TriMeH3K27 binding in HeLa cells (human cervix epithelial adenocarcinoma cells) using RenLab ENCODE PCR tiling array. Keywords: ChIP-chip

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

6 Samples

Download data: GPR

(Submitter supplied) GWLA analysis of a few promoter and enhancer markers in Hela cells. Keywords: ChIP/chip

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

51 Samples

Download data: GPR, TIFF

(Submitter supplied) ChIP-on-Chip data using histone H3 acetylation antibody and H3K4 methylation antibody. Each in triplicate. Keywords: other

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

6 Samples

Download data: TIFF

(Submitter supplied) Genome-wide location analysis of TAF1 and RNA polymerase II binding in ENCODE regions of IMR90, HCT116, HeLa and THP1 cell lines. There are a total of 8 experiments, each with three replicates. Details of chromatin immunoprecipitation and data analysis can be found at Li Z, van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B (2003) A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1454

24 Samples

Download data: TIFF, TXT

(Submitter supplied) 24,537 non-repetitive sequences that are greater than 100 bps within the 44 ENCODE regions were PCR amplified. All the purified PCR products in a total of 66 384-well plates were spoted on glass slide using a contact printer. There are a total of 48 blocks, with 23 x 23 dimension in each array. Keywords = ENCODE Keywords = PCR tiling array Keywords = Bing Ren

Organism:

Homo sapiens

12 Series

280 Samples

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