GEO DataSets

(Submitter supplied) miRNA profiling in HNSCC, including 66 paired normal, peritumor and tumor tissues from the same patients, and additional 55 unpaired tumor tissues

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL8227 GPL16770

253 Samples

Download data: TXT

(Submitter supplied) Emerging evidence indicates that microRNAs (miRNAs) are often deregulated in hepatocellular carcinoma (HCC) and that some specific miRNAs are associated with the initiation and progression of HCC. Although miRNAs plays important roles in HCC tumor formation, little is known about the mechanisms that control miRNA expression in HCC. To test if miRNA genes are targeted by epigenetic modifications, miRNA expression profiling was performed in the HCC cell line SK-HEP-1 treated or untreated with 5-AzaC (DNA hypomethylating agent). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

2 Samples

Download data: TXT

(Submitter supplied) The present study is aimed at profiling the miRNA expression pattern in oral squamous cell carcinoma (OSCC) and adjacent oral mucosa to develop a new miRNA signature for oral cancer. Agilent Human miRNA Microarray v2.0 (G4470B, Agilent Technologies) was used to identify miRNAs differentially expressed in OSCC. MicroRNA processing was carried out according to the manufacturer’s instructions. Hybridized microarrays were scanned with a DNA microarray scanner (Agilent G2565BA) and features were extracted using the Agilent Feature Extraction (AFE) image analysis tool (version A.9.5.3) with default protocols and settings. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

48 Samples

Download data: TXT

(Submitter supplied) Mycosis fungoides (MF) is the most common and best studied of cutaneous T-cell lymphoma (CTCL). Three clinical cutaneous stages have been described (patch, plaque and tumor) as the disease progress developing also the disease lymph node, peripheral blood or systemic involvement in late stages. Clinical and pathologic diagnosis of early MF stages (patch and plaque) is difficult as its morphologic similarity to inflammatory dermatoses and low proportion of tumoral cells.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

29 Samples

Download data: TXT

(Submitter supplied) Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. However, little is known about the molecular pathogenesis of this disease. In this study, we performed a miRNAs expression profiling analysis of a series of 26 PTCL cases in order to find deregulated pathways or genes that could become therapeutic agents for PTCL patients.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL8227 GPL9081

30 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL2895 GPL8227

45 Samples

Download data: TXT

(Submitter supplied) Background: Myocardial infarction (MI) is the single most critical event in coronary disease. Platelets partecipate in processes that precipitate acute MI, lack nuclear DNA but retain megakaryocyte mRNAs, thus their transcriptome could provide information preceding the coronary event. Our aim was to obtain a gene expression atlas of platelets from patients with their very first acute MI (FAMI) in order to identify potential markers of precipitating factors. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

7 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL8227 GPL6480

48 Samples

Download data: TXT

(Submitter supplied) Background. One of the major limitations associated to the platinum use is the resistance that almost invariably will progress in lung and ovarian cancers. In the current study, we sought to identify epigenetically regulated miRNAs as novel biomarkers of platinum-resistance in those tumor types. Methods. We combined transcriptomic data from miRNA and mRNA under the influence of an epigenetic reactivation treatment, followed by qRT-PCR and epigenteic validations for an accurate candidate selection in 23 human cancer cell lines. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

24 Samples

Download data: TXT

(Submitter supplied) Malignant melanoma is the most aggressive form of skin cancer therefore it is crucial to disclose its underlying molecular mechanisms. MicroRNAs are small endogenous non-coding RNAs able to post-transcriptionally down-regulate the expression of direct target genes. Using a melanoma progression model, we identified miR-146a as a key double-acting player in melanoma malignancy. In fact, miR-146a is able to enhance tumor growth while it suppresses dissemination. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

8 Samples

Download data: TXT

(Submitter supplied) MicroRNA expression levels were assessed during the canalicular phase of normal fetal lung development at the critical time, when the distal airway epithelium proliferates and differentiates. Precise miRNA regulation is important for proper pulmonary organogenesis, supporting the delicate balance between expansion of progenitor cells and their terminal differentiation. Microarray analyses could indicate the potential involvement of miRNAs important for human pulmonary hypoplasia.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

2 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL8227 GPL9081

4 Samples

Download data: TXT

(Submitter supplied) We attempted to identify potential miRNAs that can regulate viral replication by screening host miRNAs in EV71-infected RD cells. To compare the differential expression of miRNAs in EV71-infected cells at different time points, miRNA expression profiles were analyzed using Agilent Human MicroRNA Array chips. At 5 h p.i., the expression levels of most miRNAs in EV71-infected cells were not different from those of mock-infected cells. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

4 Samples

Download data: TXT

(Submitter supplied) The main cause of death in medulloblastoma is recurrence associated with leptomeningeal dissemination. Although the molecular basis of medulloblastoma has received considerable attention over the past decade, the role of microRNAs (miRNAs) in the acquisition of metastatic phenotype remains poorly understood. This study aimed to identify miRNA involved in leptomeningeal dissemination and to elucidate its target mechanisms. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

29 Samples

Download data: TXT

(Submitter supplied) Microarray data of human fetal lungs between 16-23 weeks of gestation. The results provide a general insight into the microRNA expression profile during the canalicular phase of lung development.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array; Genome variation profiling by array; Expression profiling by array

Platforms:

GPL8687 GPL4133 GPL8227

24 Samples

Download data: TXT

(Submitter supplied) Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclones comparative Genome hybridization (arrayCGH) for DNA copy number analysis gene expression and micro-RNA expression arrays were performed.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8227

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4133 GPL8227

44 Samples

Download data: TXT

(Submitter supplied) The identification of molecular signatures specific to distinct tumor types is urgently required for the design of therapies overcoming treatment resistance. It remains unclear whether such signatures are shared among tumors and corresponding cell lines, a key issue given the use of cell lines for drug development. We developed SCA (similarity core analysis) an unsupervised computational framework for extracting the core molecular features common to tumors and corresponding cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8227

21 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array; Non-coding RNA profiling by array

Platforms:

GPL9128 GPL6480 GPL8227

50 Samples

Download data: TXT