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Items: 14

1.

Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells [ATAC-seq]

(Submitter supplied) To dissect the molecular mechanisms of the transcription factor FOXA2 accessing nucleosomal targets and controlling cell fates, we combined live-cell single-molecule imaging, genome editing, chromatin binding, chromatin accessibility, and RNA sequence analysis. Using the hESC differentiation cellular system to anterior primitive streak (APS) and definitive endoderm (DE), we demonstrated by RNA-seq that FOXA2 is a lineage-determining transcription factor for DE formation and that its intrinsically disordered C-terminal domain (CTD) is essential for its normal function. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: BED, BW
Series
Accession:
GSE203649
ID:
200203649
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

ATAC_U2OS_WT_SOX2_CellLine_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BW
Sample
Accession:
GSM7996374
ID:
307996374
4.

ATAC_U2OS_WT_SOX2_CellLine_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996373
ID:
307996373
5.

ATAC_U2OS_SOX2FLFOXA2CTD_day4_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BW
Sample
Accession:
GSM7996372
ID:
307996372
6.

ATAC_U2OS_SOX2FLFOXA2CTD_day4_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996371
ID:
307996371
7.

ATAC_U2OS_SOX2FL_day4_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BW
Sample
Accession:
GSM7996370
ID:
307996370
8.

ATAC_U2OS_SOX2FL_day4_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996369
ID:
307996369
9.

ATAC_U2OS_FOXA2dCTD_day4_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996368
ID:
307996368
10.

ATAC_U2OS_FOXA2dCTD_day4_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996367
ID:
307996367
11.

ATAC_U2OS_FOXA2FL_day4_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996364
ID:
307996364
12.

ATAC_U2OS_FOXA2FL_day4_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996363
ID:
307996363
13.

ATAC_U2OS_WT_biol rep2

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996360
ID:
307996360
14.

ATAC_U2OS_WT_biol rep1

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL24676
Series:
GSE203649 GSE203650
Download data: BED, BW
Sample
Accession:
GSM7996359
ID:
307996359
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Supplemental Content

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