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1.

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(Submitter supplied) BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacetylation through HDAC3, antagonized p300 activity and repressed transcription, but without decommissioning enhancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15433 GPL10999 GPL11154
46 Samples
Download data: BED, BW, TXT, WIG
2.

Illumina HiSeq 1000 (Homo sapiens)

Platform
Accession:
GPL15433
ID:
100015433
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Illumina Genome Analyzer IIx (Homo sapiens)

Platform
Accession:
GPL10999
ID:
100010999
5.

OCI-LY1_48hrs_mRNAseq_3x_siBCL6_R3

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000986
ID:
301000986
6.

OCI-LY1_48hrs_mRNAseq_3x_siBCL6_R2

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000985
ID:
301000985
7.

OCI-LY1_48hrs_mRNAseq_3x_siBCL6_R1

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000984
ID:
301000984
8.

OCI-LY1_48hrs_mRNAseq_3x_siNT_R3

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000983
ID:
301000983
9.

OCI-LY1_48hrs_mRNAseq_3x_siNT_R2

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000982
ID:
301000982
10.

OCI-LY1_48hrs_mRNAseq_3x_siNT_R1

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000981
ID:
301000981
11.

GCB_rep2_INPUT

Organism:
Homo sapiens
Source name:
Germinal center B cells
Platform:
GPL15433
Series:
GSE29282
Download data: WIG
Sample
Accession:
GSM1000980
ID:
301000980
12.

GCB_rep2_BCL6_CHIP

Organism:
Homo sapiens
Source name:
Germinal center B cells
Platform:
GPL15433
Series:
GSE29282
Download data: BED, WIG
Sample
Accession:
GSM1000979
ID:
301000979
13.

OCI-LY1_H3K27Ac_ChIP-seq:siNT

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL11154
Series:
GSE29282
Download data: WIG
Sample
Accession:
GSM898059
ID:
300898059
14.

OCI-LY1_H3K27Ac_ChIP-seq:siBCL6

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL11154
Series:
GSE29282
Download data: WIG
Sample
Accession:
GSM898058
ID:
300898058
15.

OCI-LY1_siNT_48hrs_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756313
ID:
300756313
16.

OCI-LY1_siNT_24hrs_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756312
ID:
300756312
17.

OCI-LY1_siBCL6_48hrs_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756311
ID:
300756311
18.

OCI-LY1_siBCL6_24hrs_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756310
ID:
300756310
19.

OCI-LY1_Control_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756309
ID:
300756309
20.

OCI-LY1_NCOR-p300_INPUT

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL10999
Series:
GSE29282
Download data: WIG
Sample
Accession:
GSM898057
ID:
300898057
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Supplemental Content

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