GEO DataSets

(Submitter supplied) One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not induce DNA breaks. We define a new activity for the antracyclines: unsupported histone eviction from ´open´ or loosely packed chromosomal areas reflecting exon and promoter regions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13376

14 Samples

Download data: TXT

(Submitter supplied) Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. Instructions for assembling a GEOarchive may be found at http://www.ncbi.nlm.nih.gov/projects/geo/info/spreadsheet.html HumanWG-6_V2_0_R4_11223189_A.txt Protocol: see manufacturer's website

Organism:

Homo sapiens

30 Series

1584 Samples

Download data: TXT