GSE63581[Accession] - GEO DataSets - NCBI

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Select item 2000635811.

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [ChIP-Seq]

(Submitter supplied) Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. Here we report the preferential and high sensitivity of TNBCs to BET bromodomain inhibitors such as JQ1 manifested by cell cycle arrest in early G1, apoptosis, and induction of markers of luminal epithelial differentiation in vitro and in vivo. The sensitivity of TNBC and other tumor types to BET inhibition establishes a rationale for clinical investigation, and a motivation to understand mechanisms of resistance. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL18573
35 Samples

Download data: WIG

Series

Accession:: GSE63581

ID:: 200063581

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12044 Series
332532 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10425 Series
180579 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3018427214.

Organism:: Homo sapiens

Source name:: T47D

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842721

ID:: 301842721

SRA Run Selector

Select item 3018427205.

Organism:: Homo sapiens

Source name:: T47D

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842720

ID:: 301842720

SRA Run Selector

Select item 3018427196.

Organism:: Homo sapiens

Source name:: T47D

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842719

ID:: 301842719

SRA Run Selector

Select item 3018427187.

SUM185_WCE_DMSO

Organism:: Homo sapiens

Source name:: SUM185

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842718

ID:: 301842718

SRA Run Selector

Select item 3018427178.

SUM185_BRD4_JQ1

Organism:: Homo sapiens

Source name:: SUM185

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842717

ID:: 301842717

SRA Run Selector

Select item 3018427169.

SUM185_BRD4_DMSO

Organism:: Homo sapiens

Source name:: SUM185

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842716

ID:: 301842716

SRA Run Selector

Select item 30184271510.

SUM149_WCE_DMSO

Organism:: Homo sapiens

Source name:: SUM149

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842715

ID:: 301842715

SRA Run Selector

Select item 30184271411.

SUM149_H3K27AC_JQ1

Organism:: Homo sapiens

Source name:: SUM149

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842714

ID:: 301842714

SRA Run Selector

Select item 30184271312.

SUM149_H3K27AC_DMSO

Organism:: Homo sapiens

Source name:: SUM149

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842713

ID:: 301842713

SRA Run Selector

Select item 30184271213.

SUM149_BRD4_JQ1

Organism:: Homo sapiens

Source name:: SUM149

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842712

ID:: 301842712

SRA Run Selector

Select item 30184271114.

SUM149_BRD4_DMSO

Organism:: Homo sapiens

Source name:: SUM149

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842711

ID:: 301842711

SRA Run Selector

Select item 30184271015.

SUM149R_WCE_DMSO

Organism:: Homo sapiens

Source name:: SUM149R

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842710

ID:: 301842710

SRA Run Selector

Select item 30184270916.

SUM149R_H3K27AC_JQ1

Organism:: Homo sapiens

Source name:: SUM149R

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842709

ID:: 301842709

SRA Run Selector

Select item 30184270817.

SUM149R_H3K27AC_DMSO

Organism:: Homo sapiens

Source name:: SUM149R

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842708

ID:: 301842708

SRA Run Selector

Select item 30184270718.

SUM149R_BRD4_JQ1

Organism:: Homo sapiens

Source name:: SUM149R

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842707

ID:: 301842707

SRA Run Selector

Select item 30184270619.

SUM149R_BRD4_DMSO

Organism:: Homo sapiens

Source name:: SUM149R

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842706

ID:: 301842706

SRA Run Selector

Select item 30184270520.

SUM1315_WCE_DMSO

Organism:: Homo sapiens

Source name:: SUM1315

Platform:: GPL18573
Series:: GSE63581 GSE63584

Download data: WIG

Sample

Accession:: GSM1842705

ID:: 301842705

SRA Run Selector

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