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Items: 1 to 20 of 31

1.

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer [RNA-Seq]

(Submitter supplied) Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. Here we report the preferential and high sensitivity of TNBCs to BET bromodomain inhibitors such as JQ1 manifested by cell cycle arrest in early G1, apoptosis, and induction of markers of luminal epithelial differentiation in vitro and in vivo. The sensitivity of TNBC and other tumor types to BET inhibition establishes a rationale for clinical investigation, and a motivation to understand mechanisms of resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
28 Samples
Download data: TXT
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

SUM149_JQ1_12H_R2

Organism:
Homo sapiens
Source name:
SUM149
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842500
ID:
301842500
5.

SUM149_JQ1_12H_R1

Organism:
Homo sapiens
Source name:
SUM149
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842499
ID:
301842499
6.

SUM149_DMSO_12H_R2

Organism:
Homo sapiens
Source name:
SUM149
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842498
ID:
301842498
7.

SUM149_DMSO_12H_R1

Organism:
Homo sapiens
Source name:
SUM149
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842497
ID:
301842497
8.

SUM149R_JQ1_12H_R2

Organism:
Homo sapiens
Source name:
SUM149R
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842496
ID:
301842496
9.

SUM149R_JQ1_12H_R1

Organism:
Homo sapiens
Source name:
SUM149R
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842495
ID:
301842495
10.

SUM149R_DMSO_12H_R2

Organism:
Homo sapiens
Source name:
SUM149R
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842494
ID:
301842494
11.

SUM149R_DMSO_12H_R1

Organism:
Homo sapiens
Source name:
SUM149R
Platform:
GPL18573
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1842493
ID:
301842493
12.

SUM159_JQ1_3H_2

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553163
ID:
301553163
13.

SUM159_JQ1_3H_1

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553162
ID:
301553162
14.

SUM159_JQ1_24H_2

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553161
ID:
301553161
15.

SUM159_JQ1_24H_1

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553160
ID:
301553160
16.

SUM159_JQ1_12H_2

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553159
ID:
301553159
17.

SUM159_JQ1_12H_1

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553158
ID:
301553158
18.

SUM159_DMSO_3H_2

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553157
ID:
301553157
19.

SUM159_DMSO_3H_1

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553156
ID:
301553156
20.

SUM159_DMSO_24H_2

Organism:
Homo sapiens
Source name:
SUM159
Platform:
GPL11154
Series:
GSE63582 GSE63584
Download data
Sample
Accession:
GSM1553155
ID:
301553155
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Supplemental Content

db=gds|term=GSE63582[Accession]|query=1|qty=2|blobid=MCID_666b48ac6e9d376f23180586|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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