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Items: 1 to 20 of 50

1.

Ubiquitin-dependent turnover of MYC promotes loading of the PAF complex on RNA Polymerase II to drive transcriptional elongation (RNA-seq)

(Submitter supplied) The MYC transcription factor is an unstable protein and its turnover is controlled by the ubiquitin system. Ubiquitination enhances MYC-dependent transactivation, but the underlying mechanism remains unresolved. Here we show that proteasomal turnover of MYC is dispensable for recruitment of RNA polymerase II (RNAPII), but is required to promote transcriptional elongation at MYC target genes. Degradation of MYC stimulates histone acetylation and recruitment of BRD4 and P-TEFb to target promoters, leading to phosphorylation of RNAPII CTD and the release of elongating RNAPII. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL10999
47 Samples
Download data: BEDGRAPH, CSV
Series
Accession:
GSE70000
ID:
200070000

PubMed Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12045 Series
332544 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

Illumina Genome Analyzer IIx (Homo sapiens)

Organism:
Homo sapiens
1097 Series
9999 Samples
Download data
Platform
Accession:
GPL10999
ID:
100010999

4.

plus_mg_wt_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715543
ID:
301715543

SRA Run Selector

5.

plus_mg_wt_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715542
ID:
301715542

SRA Run Selector

6.

plus_mg_swap_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715541
ID:
301715541

SRA Run Selector

7.

plus_mg_swap_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715540
ID:
301715540

SRA Run Selector

8.

plus_mg_kless_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715539
ID:
301715539

SRA Run Selector

9.

plus_mg_kless_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715538
ID:
301715538

SRA Run Selector

10.

minus_mg_wt_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715537
ID:
301715537

SRA Run Selector

11.

minus_mg_wt_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715536
ID:
301715536

SRA Run Selector

12.

minus_mg_swap_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715535
ID:
301715535

SRA Run Selector

13.

minus_mg_swap_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715534
ID:
301715534

SRA Run Selector

14.

minus_mg_kless_etoh.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715533
ID:
301715533

SRA Run Selector

15.

minus_mg_kless_dox.fastq

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715532
ID:
301715532

SRA Run Selector

16.

siskp2_wt_etoh

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715531
ID:
301715531

SRA Run Selector

17.

siskp2_wt_dox

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715530
ID:
301715530

SRA Run Selector

18.

sictrl_wt_etoh

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715529
ID:
301715529

SRA Run Selector

19.

sictrl_wt_dox

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715528
ID:
301715528

SRA Run Selector

20.

rep2_wt_etoh

Organism:
Homo sapiens
Source name:
IMEC cell line
Platform:
GPL10999
Series:
GSE70000 GSE70009
Download data
Sample
Accession:
GSM1715527
ID:
301715527

SRA Run Selector

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