GSE77328[Accession] - GEO DataSets - NCBI

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Select item 2000773281.

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

(Submitter supplied) MYC genes have both essential roles during normal development and exert oncogenic functions during tumorigenesis. Expression of a dominant-negative allele of MYC, termed OmoMYC, can induce rapid tumor regression in mouse models with little toxicity for normal tissues. How OmoMYC discriminates between physiological and oncogenic functions of MYC is unclear. We have solved the crystal structure of OmoMYC and show that it forms a stable homodimer and as such recognizes DNA in the same manner as the MYC/MAX heterodimer. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL18573 GPL19057 GPL11002
44 Samples

Download data: TXT, WIG

Series

Accession:: GSE77328

ID:: 200077328

PubMed Similar studies SRA Run Selector

Select item 1000190572.

Illumina NextSeq 500 (Mus musculus)

Organism:: Mus musculus

9798 Series
285101 Samples

Platform

Accession:: GPL19057

ID:: 100019057

Select item 1000185733.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12044 Series
332532 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 1000110024.

Illumina Genome Analyzer IIx (Mus musculus)

Organism:: Mus musculus

895 Series
7710 Samples

Platform

Accession:: GPL11002

ID:: 100011002

Select item 3020493575.

KPC_shRNA_screen_-Dox_rep4

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049357

ID:: 302049357

SRA Run Selector

Select item 3020493566.

KPC_shRNA_screen_+Dox_rep4

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049356

ID:: 302049356

SRA Run Selector

Select item 3020493557.

KPC_shRNA_screen_-Dox_rep3

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049355

ID:: 302049355

SRA Run Selector

Select item 3020493548.

KPC_shRNA_screen_+Dox_rep3

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049354

ID:: 302049354

SRA Run Selector

Select item 3020493539.

KPC_shRNA_screen_-Dox_rep2

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049353

ID:: 302049353

SRA Run Selector

Select item 30204935210.

KPC_shRNA_screen_+Dox_rep2

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049352

ID:: 302049352

SRA Run Selector

Select item 30204935111.

KPC_shRNA_screen_-Dox_rep1

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049351

ID:: 302049351

SRA Run Selector

Select item 30204935012.

KPC_shRNA_screen_+Dox_rep1

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL11002
Series:: GSE77328

Sample

Accession:: GSM2049350

ID:: 302049350

SRA Run Selector

Select item 30204934913.

KPC_OmoMYC_+Dox_rep2

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL19057
Series:: GSE77328

Sample

Accession:: GSM2049349

ID:: 302049349

SRA Run Selector

Select item 30204934814.

KPC_OmoMYC_+Dox_rep1

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL19057
Series:: GSE77328

Sample

Accession:: GSM2049348

ID:: 302049348

SRA Run Selector

Select item 30204934715.

KPC_OmoMYC_-Dox_rep2

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL19057
Series:: GSE77328

Sample

Accession:: GSM2049347

ID:: 302049347

SRA Run Selector

Select item 30204934616.

KPC_OmoMYC_-Dox_rep1

Organism:: Mus musculus

Source name:: KPC cells

Platform:: GPL19057
Series:: GSE77328

Sample

Accession:: GSM2049346

ID:: 302049346

SRA Run Selector

Select item 30204934517.

U2OS_exp2_OmoMYCmutHER_+Dox_rep3

Organism:: Homo sapiens

Source name:: U2OS cells

Platform:: GPL18573
Series:: GSE77328

Sample

Accession:: GSM2049345

ID:: 302049345

SRA Run Selector

Select item 30204934418.

U2OS_exp2_OmoMYCmutHER_+Dox_rep2

Organism:: Homo sapiens

Source name:: U2OS cells

Platform:: GPL18573
Series:: GSE77328

Sample

Accession:: GSM2049344

ID:: 302049344

SRA Run Selector

Select item 30204934319.

U2OS_exp2_OmoMYCmutHER_+Dox_rep1

Organism:: Homo sapiens

Source name:: U2OS cells

Platform:: GPL18573
Series:: GSE77328

Sample

Accession:: GSM2049343

ID:: 302049343

SRA Run Selector

Select item 30204934220.

U2OS_exp2_OmoMYCmutHE_+Dox_rep3

Organism:: Homo sapiens

Source name:: U2OS cells

Platform:: GPL18573
Series:: GSE77328

Sample

Accession:: GSM2049342

ID:: 302049342

SRA Run Selector

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