GSE78801[Accession] - GEO DataSets - NCBI

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Select item 2000788011.

Heterotypic nucleosomes and PRC2 drive DIPG oncogenesis

(Submitter supplied) Diffuse intrinsic pontine gliomas (DIPG) are characterized by a heterozygous lysine-to-methionine mutation of histone H3 (H3K27M) that potently reduces Polycomb Repressive Complex 2 (PRC2) methylation of wild-type histone H3K27 (H3K27wt). The role of H3K27M and reduced H3K27wt methylation in DIPG pathogenesis has yet to be determined. Here, we have performed epigenomic profiling of patient-derived H3K27M mutant DIPG cells and demonstrate that H3K27M resides in nucleosomes with H3K27wt acetylation (H3K27ac), and H3K27M-H3K27ac containing nucleosomes co-localize with bromodomain proteins at actively transcribed genes and that PRC2 is excluded from H3K27M occupied regions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
100 Samples

Download data: BW

Series

Accession:: GSE78801

ID:: 200078801

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12045 Series
332544 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 3022657233.

DUIV_shSUZ12_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265723

ID:: 302265723

SRA Run Selector

Select item 3022657224.

DUIV_shSUZ12_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265722

ID:: 302265722

SRA Run Selector

Select item 3022657215.

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265721

ID:: 302265721

SRA Run Selector

Select item 3022657206.

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265720

ID:: 302265720

SRA Run Selector

Select item 3022657197.

SF8628_shSUZ12_rep2

Organism:: Homo sapiens

Source name:: SF8628 (H3.3K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265719

ID:: 302265719

SRA Run Selector

Select item 3022657188.

SF8628_shSUZ12_rep1

Organism:: Homo sapiens

Source name:: SF8628 (H3.3K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265718

ID:: 302265718

SRA Run Selector

Select item 3022657179.

SF8628_CTRL_rep2

Organism:: Homo sapiens

Source name:: SF8628 (H3.3K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265717

ID:: 302265717

SRA Run Selector

Select item 30226571610.

SF8628_CTRL_rep1

Organism:: Homo sapiens

Source name:: SF8628 (H3.3K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265716

ID:: 302265716

SRA Run Selector

Select item 30226571511.

SU_DIPG_IV_JQ1_300nM_48h_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265715

ID:: 302265715

SRA Run Selector

Select item 30226571412.

SU_DIPG_IV_JQ1_300nM_24h_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265714

ID:: 302265714

SRA Run Selector

Select item 30226571313.

SU_DIPG_IV_JQ1_300nM_12h_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265713

ID:: 302265713

SRA Run Selector

Select item 30226571214.

SU_DIPG_IV_ JQ1_300nM_6h_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265712

ID:: 302265712

SRA Run Selector

Select item 30226571115.

SU_DIPG_IV_JQ1_300nM_3h_rep2

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265711

ID:: 302265711

SRA Run Selector

Select item 30226571016.

SU_DIPG_IV_JQ1_300nM_48h_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265710

ID:: 302265710

SRA Run Selector

Select item 30226570917.

SU_DIPG_IV_JQ1_300nM_24h_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265709

ID:: 302265709

SRA Run Selector

Select item 30226570818.

SU_DIPG_IV_JQ1_300nM_12h_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265708

ID:: 302265708

SRA Run Selector

Select item 30226570719.

SU_DIPG_IV_ JQ1_300nM_6h_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265707

ID:: 302265707

SRA Run Selector

Select item 30226570620.

SU_DIPG_IV_JQ1_300nM_3h_rep1

Organism:: Homo sapiens

Source name:: DIPG_SU_IV (H3.1K27M)

Platform:: GPL18573
Series:: GSE78801

Download data: BW

Sample

Accession:: GSM2265706

ID:: 302265706

SRA Run Selector

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