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Items: 6

1.

Epigenetic targeting of immunocheckpoint PD-L1 by BET bromodomain inhibition

(Submitter supplied) Epigenetic regulators have emerged as exciting targets for cancer therapy. Additionally, restoration of antitumor immunity by blocking the PD-L1 signaling using antibodies has proven to be beneficial in cancer therapy. Here we show that BET bromodomain inhibition suppresses PD-L1 expression and restores antitumor immunity in ovarian cancer. CD274 (encoding PD-L1) is a direct target of BRD4-mediated gene transcription. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: TXT
Series
Accession:
GSE81698
ID:
200081698

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12044 Series
332532 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

RNA-seq for BRD4 knockdown cells

Organism:
Homo sapiens
Source name:
PEO1 ovarian cancer cells
Platform:
GPL18573
Series:
GSE81698
Download data
Sample
Accession:
GSM2171433
ID:
302171433

SRA Run Selector

4.

RNA-seq for BRD4 wild type cells

Organism:
Homo sapiens
Source name:
PEO1 ovarian cancer cells
Platform:
GPL18573
Series:
GSE81698
Download data
Sample
Accession:
GSM2171432
ID:
302171432

SRA Run Selector

5.

RNA-seq for JQ1 treated cells

Organism:
Homo sapiens
Source name:
PEO1 ovarian cancer cells
Platform:
GPL18573
Series:
GSE81698
Download data
Sample
Accession:
GSM2171431
ID:
302171431

SRA Run Selector

6.

RNA-seq for DMSO treated cells

Organism:
Homo sapiens
Source name:
PEO1 ovarian cancer cells
Platform:
GPL18573
Series:
GSE81698
Download data
Sample
Accession:
GSM2171430
ID:
302171430

SRA Run Selector

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db=gds|term=GSE81698[Accession]|query=1|qty=2|blobid=MCID_666b16dd909a3d46ad7465d9|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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