GSE83772[Accession] - GEO DataSets - NCBI

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Select item 2000837721.

The FAM46C gene encodes a non-canonical poly(A) polymerase and acts as an onco-suppressor in multiple myeloma

(Submitter supplied) FAM46C is one of the most frequently mutated genes in multiple myeloma (MM) and encodes a protein of unknown function. Using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active cytoplasmic non-canonical poly(A) polymerase, which enhances mRNA stability and gene expression. Moreover, we also found that the reintroduction of active FAM46C into MM cell lines, but not its catalytically-inactive mutant, leads to broad polyadenylation and stabilization of mRNAs strongly enriched with those encoding endoplasmic reticulum-targeted proteins and induced cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL11154
26 Samples

Download data: BW, TXT

Series

Accession:: GSE83772

ID:: 200083772

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000185732.

Illumina NextSeq 500 (Homo sapiens)

Organism:: Homo sapiens

12044 Series
332532 Samples

Platform

Accession:: GPL18573

ID:: 100018573

Select item 1000111543.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10425 Series
180579 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3022187204.

H929 cells expressing FAM46CWTGFP for 72 hrs rep4_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218720

ID:: 302218720

SRA Run Selector

Select item 3022187195.

H929 cells expressing FAM46CWTGFP for 72 hrs rep3_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218719

ID:: 302218719

SRA Run Selector

Select item 3022187186.

H929 cells expressing FAM46CWTGFP for 72 hrs rep2_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218718

ID:: 302218718

SRA Run Selector

Select item 3022187177.

H929 cells expressing FAM46CWTGFP for 72 hrs rep1_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218717

ID:: 302218717

SRA Run Selector

Select item 3022187168.

H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep4_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218716

ID:: 302218716

SRA Run Selector

Select item 3022187159.

H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep3_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218715

ID:: 302218715

SRA Run Selector

Select item 30221871410.

H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep2_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218714

ID:: 302218714

SRA Run Selector

Select item 30221871311.

H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep1_total RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218713

ID:: 302218713

SRA Run Selector

Select item 30221871212.

SKMM1 cells expressing FAM46CWTGFP for 72 hrs rep3_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218712

ID:: 302218712

SRA Run Selector

Select item 30221871113.

SKMM1 cells expressing FAM46CWTGFP for 72 hrs rep2_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218711

ID:: 302218711

SRA Run Selector

Select item 30221871014.

SKMM1 cells expressing FAM46CWTGFP for 72 hrs rep1_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218710

ID:: 302218710

SRA Run Selector

Select item 30221870915.

SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep3_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218709

ID:: 302218709

SRA Run Selector

Select item 30221870816.

SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep2_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218708

ID:: 302218708

SRA Run Selector

Select item 30221870717.

SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs rep1_polyA RNA

Organism:: Homo sapiens

Source name:: SKMM1 cells expressing FAM46CD90A,D92AGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218707

ID:: 302218707

SRA Run Selector

Select item 30221870618.

H929 cells expressing FAM46CWTGFP for 72 hrs rep3_polyA RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218706

ID:: 302218706

SRA Run Selector

Select item 30221870519.

H929 cells expressing FAM46CWTGFP for 72 hrs rep2_polyA RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218705

ID:: 302218705

SRA Run Selector

Select item 30221870420.

H929 cells expressing FAM46CWTGFP for 72 hrs rep1_polyA RNA

Organism:: Homo sapiens

Source name:: H929 cells expressing FAM46CWTGFP for 72 hrs

Platform:: GPL11154
Series:: GSE83772

Download data: BW, TXT

Sample

Accession:: GSM2218704

ID:: 302218704

SRA Run Selector

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