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Items: 7

1.

ARID1A-mutated ovarian cancers depend on HDAC6 activity

(Submitter supplied) ARID1A, encoding a subunit of the SWI/SNF chromatin remodeling complex, is the most mutated epigenetic regulator in human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with ARID1A mutational status remain a challenge. Here, we show that HDAC6 activity is essential in ARID1A-mutated ovarian cancers. Inhibition of HDAC6 activity using a clinically applicable small molecule inhibitor significantly improved the survival of mice bearing ARID1A-mutated ovarian tumors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
5 Samples
Download data: TXT
Series
Accession:
GSE84405
ID:
200084405

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12044 Series
332532 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

CAY10603

Organism:
Homo sapiens
Source name:
TOV21G cell line
Platform:
GPL18573
Series:
GSE84405
Download data
Sample
Accession:
GSM2233133
ID:
302233133

SRA Run Selector

4.

ACY1215

Organism:
Homo sapiens
Source name:
TOV21G cell line
Platform:
GPL18573
Series:
GSE84405
Download data
Sample
Accession:
GSM2233132
ID:
302233132

SRA Run Selector

5.

shHDAC6

Organism:
Homo sapiens
Source name:
TOV21G cell line
Platform:
GPL18573
Series:
GSE84405
Download data
Sample
Accession:
GSM2233131
ID:
302233131

SRA Run Selector

6.

Vehicle control

Organism:
Homo sapiens
Source name:
TOV21G cell line
Platform:
GPL18573
Series:
GSE84405
Download data
Sample
Accession:
GSM2233130
ID:
302233130

SRA Run Selector

7.

shControl

Organism:
Homo sapiens
Source name:
TOV21G cell line
Platform:
GPL18573
Series:
GSE84405
Download data
Sample
Accession:
GSM2233129
ID:
302233129

SRA Run Selector

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db=gds|term=GSE84405[Accession]|query=1|qty=2|blobid=MCID_666ad3484f49d52cd28ab16d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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