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Items: 20

1.

MEK inhibition rewires enhancer landscapes in RAS-driven Rhabdomyosarcoma to unlock a myogenic differentation block

(Submitter supplied) Trametinib-treated rhabdomyosarcoma cells undergo transcriptional reprogramming akin to myogenic differentiation. This reprogramming is induced by loss of ERK-mediated inhibition of MYOG expression. Restoration of MYOG allows establishment of super-enhancers at genes expressed by terminally differentiated myotubes. Our findings demonstrate that aberrant MAP kinase activity blocks differentiation in rhabdomyosarcoma and highlight trametinib as a potential therapeutic for RAS-mutated rhabdomyosarcoma.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
18 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE85170
ID:
200085170

Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12044 Series
332532 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

RD 100 nM Tram, 48 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259176
ID:
302259176

SRA Run Selector

4.

RD 100 nM Tram, 24 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259175
ID:
302259175

SRA Run Selector

5.

RD 100 nM Tram, 6 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259174
ID:
302259174

SRA Run Selector

6.

RD 10 nM Tram, 48 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259173
ID:
302259173

SRA Run Selector

7.

RD 10 nM Tram, 24 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259172
ID:
302259172

SRA Run Selector

8.

RD 10 nM Tram, 6 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259171
ID:
302259171

SRA Run Selector

9.

RD DMSO

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259170
ID:
302259170

SRA Run Selector

10.

RD untreated

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259169
ID:
302259169

SRA Run Selector

11.

RD si MEK1

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259168
ID:
302259168

SRA Run Selector

12.

RD si control

Organism:
Homo sapiens
Source name:
RMS cell line, mutant NRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259167
ID:
302259167

SRA Run Selector

13.

CTR 100 nM Tram, 48 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259166
ID:
302259166

SRA Run Selector

14.

CTR 100 nM Tram, 24 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259165
ID:
302259165

SRA Run Selector

15.

CTR 100 nM Tram, 6 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259164
ID:
302259164

SRA Run Selector

16.

CTR 10 nM Tram, 48 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259163
ID:
302259163

SRA Run Selector

17.

CTR 10 nM Tram, 24 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259162
ID:
302259162

SRA Run Selector

18.

CTR 10 nM Tram, 6 hrs

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259161
ID:
302259161

SRA Run Selector

19.

CTR DMSO

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259160
ID:
302259160

SRA Run Selector

20.

CTR untreated

Organism:
Homo sapiens
Source name:
RMS cell line, mutant HRAS
Platform:
GPL18573
Series:
GSE85170 GSE85171
Download data: FPKM_TRACKING
Sample
Accession:
GSM2259159
ID:
302259159

SRA Run Selector

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db=gds|term=GSE85170[Accession]|query=1|qty=2|blobid=MCID_666b7a62909a3d46ad7d496c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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