GSM1045355[Accession] - GEO DataSets

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Items: 4

Select item 2000425761.

CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16332 GPL11154
14 Samples

Download data: BED, CEL, TXT

Series

Accession:: GSE42576

ID:: 200042576

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000425742.

CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [gene expression]

(Submitter supplied) The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of restriction factors. Recently, the cellular transcription cofactor CBFb was shown to form a complex with CRL5-Vif and to be essential for A3 degradation and viral infectivity. We now demonstrate that CBFb is required for assembling a well-ordered CRL5-Vif complex by inhibiting Vif oligomerization and by activating CRL5-Vif via direct interaction. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16332
12 Samples

Download data: CEL

Series

Accession:: GSE42574

ID:: 200042574

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000163323.

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [MMBGX-Ensembl64]

(Submitter supplied) This platform contains certain probeset groupings used for analysis with the MMBGX software platform (PMID 19854940) http://www.bgx.org.uk/software/mmbgx.html For data processing, the MMBGX software suite uses raw data CEL files directly as input. Protocol: See manufacturer's web site