GSM1325078[Accession] - GEO DataSets

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Items: 4

Select item 2000548471.

Exploring the role of macroH2A1 in transcription regulation in IMR90 primary human lung fibroblasts with RNA-seq and ChIP-seq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
10 Samples

Download data: BEDGRAPH, GAPPEDPEAK, TXT

Series

Accession:: GSE54847

ID:: 200054847

PubMed Full text in PMC Similar studies

Select item 2000548462.

RNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts

(Submitter supplied) The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact with poly(ADP-ribose). Using ChIP-seq in primary lung fibroblasts, we demonstrate that macroH2A1 is incorporated into either of two spatially and functionally distinct types of chromatin; the first is marked by H3 K27 trimethylation, while the second contains a set of nine histone acetylations. more...