GSM1440655[Accession] - GEO DataSets

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Items: 4

Select item 2000596281.

Uridylation by TUT4 and TUT7 marks mRNA for degradation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL15520
30 Samples

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Series

Accession:: GSE59628

ID:: 200059628

PubMed Full text in PMC Similar studies

Select item 2000596262.

Uridylation by TUT4 and TUT7 marks mRNA for degradation [RNA-Seq]

(Submitter supplied) Uridylation occurs pervasively on mRNAs in mammals, yet its mechanism and significance remain unknown. Here we identify TUT4 and TUT7 (also known as ZCCHC11 and ZCCHC6, respectively) as the enzymes that uridylate mRNAs. Uridylation readily occurs on deadenylated mRNAs that are not associated with poly(A) binding protein (PABPC1) in cells. Consistently, purified TUT4 and TUT7 (TUT4/7) selectively uridylate RNAs with short A tails (< ~25 nt) while PABPC1 antagonizes uridylation of polyadenylated mRNAs in vitro. more...