GSM1537297[Accession] - GEO DataSets

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Items: 4

Select item 2000629661.

Analysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation

(Submitter supplied) Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the inactive X chromosome frequently displays a highly abnormal 3D nuclear organization, with global perturbations in its characteristic heterochromatic state, including apparent gain of euchromatic marks and lessening of repressive marks such as H3K27me3 and promoter DNA methylation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL11154 GPL16791
29 Samples

Download data: BEDGRAPH, FPKM_TRACKING, TXT, XLS

Series

Accession:: GSE62966

ID:: 200062966

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000629072.

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Genome variation profiling by SNP array; SNP genotyping by SNP array